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Literature DB >> 900921

Rosamicin in urethral and vaginal secretions and tissues in dogs and rats.

Abstract

In animal studies we investigated the distribution of rosamicin in plasma and urethral and vaginal tissues in rats as well as in urethral and vaginal secretions in dogs. We found concentration ratios between urethral secretion and plasma of 1.9 and between vaginal secretion and plasma of 2.4. The rosamicin concentrations in urethral and vaginal tissue significantly exceeded the levels of all other tissues investigated. Because rosamicin could be valuable for the treatment of bacterial urethritis and the colonization of the vaginal introitus with fecal bacteria in women, it should be investigated clinically in this respect.

Entities: Disease Species

Mesh：

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Year: 1977 PMID： 900921 PMCID： PMC429891 DOI： 10.1128/AAC.12.2.237

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

7 in total

1. INTRACAVITARY CIRCULATION OF AQUEOUS MATERIAL IN THE HUMAN VAGINA.

Authors: E ODEBLAD
Journal: Acta Obstet Gynecol Scand Date: 1964 Impact factor: 3.636

2. Perineal, vaginal and urethral bacteriology of young women. I. Incidence of gram-negative colonization.

Authors: I B Elkins; C E Cox
Journal: J Urol Date: 1974-01 Impact factor: 7.450

3. Urethral glands in the wall of the female urethra of rats, mice and closely related rodents.

Authors: R Shehata
Journal: Acta Anat (Basel) Date: 1974

4. A new Micromonospora-produced macrolide antibiotic, rosamicin.

Authors: G H Wagman; J A Waitz; J Marquez; A Murawaski; E M Oden; R T Testa; M J Weinstein
Journal: J Antibiot (Tokyo) Date: 1972-11 Impact factor: 2.649

5. Recurrent urinary infections in adult women. The role of introital enterobacteria.

Authors: T A Stamey; M Timothy; M Millar; G Mihara
Journal: Calif Med Date: 1971-07

6. The diffusion and concentration of trimethoprim in human vaginal fluid.

Authors: T A Stamey; M Condy
Journal: J Infect Dis Date: 1975-03 Impact factor: 5.226

7. Prostatic antibacterial factor. Identity and significance.

Authors: W R Fair; J Couch; N Wehner
Journal: Urology Date: 1976-02 Impact factor: 2.649

7 in total

6 in total

1. In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae.

Authors: J W Biddle; C Thornsberry
Journal: Antimicrob Agents Chemother Date: 1979-02 Impact factor: 5.191

Rosamicin in urethral and vaginal secretions and tissues in dogs and rats.

1. INTRACAVITARY CIRCULATION OF AQUEOUS MATERIAL IN THE HUMAN VAGINA.

2. Perineal, vaginal and urethral bacteriology of young women. I. Incidence of gram-negative colonization.

3. Urethral glands in the wall of the female urethra of rats, mice and closely related rodents.

4. A new Micromonospora-produced macrolide antibiotic, rosamicin.

5. Recurrent urinary infections in adult women. The role of introital enterobacteria.

6. The diffusion and concentration of trimethoprim in human vaginal fluid.

7. Prostatic antibacterial factor. Identity and significance.

1. In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae.

2. The influence of pH on antimicrobial substances in canine vaginal and urethral secretions.

3. In vitro activity of rosamicin and erythromycin against a group of nonfermenting gram-negative bacilli.

4. Molecular and phenotypic characterization of penicillinase-producing Neisseria gonorrhoeae from Canadian sources.

5. In vitro susceptibility of 30 strains of Chlamydia trachomatis to rosamicin.

6. High-pressure liquid chromatographic method for determination of rosaramicin in humans.