Literature DB >> 900917

In vitro uptake of gentamicin by rat renal cortical tissue.

C H Hsu, T W Kurtz, J M Weller.   

Abstract

The mechanism of gentamicin uptake in vitro by renal cortical slices of rat kidney was investigated. The cortical-slice-uptake ratio of gentamicin concentration in 1.0 g of tissue water to that of 1.0 ml of incubation medium (SW/M) was 1.44 +/- 0.04. The uptake of gentamicin was inhibited by 2 x 10(-5) M dinitrophenol (SW/M = 1.03 +/- 0.04) and by anoxia (SW/M = 1.01 +/- 0.04). The results indicate that aerobic phosphorylation is required to transport gentamicin into the cells. The uptake of p-aminohippurate and tetraethylammonium chloride by renal cortical slices was not affected by gentamicin.

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Year:  1977        PMID： 900917      PMCID： PMC429883          DOI： 10.1128/AAC.12.2.192

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

Review 1.  RENAL TUBULAR MECHANISMS FOR EXCRETION OF ORGANIC ACIDS AND BASES.

Authors:  I M WEINER; G H MUDGE
Journal:  Am J Med       Date:  1964-05       Impact factor: 4.965

2.  Renal tubular transport: accumulation of p-aminohippurate by rabbit kidney slices.

Authors:  R J CROSS; J V TAGGART
Journal:  Am J Physiol       Date:  1950-04-01

3.  The role of tubular necrosis in the pathophysiology of acute renal failure.

Authors:  C H Hsu; T W Kurtz; J M Weller
Journal:  Nephron       Date:  1976       Impact factor: 2.847

Review 4.  Editorial: Intrarenal antibiotic distribution in health and disease.

Authors:  A Whelton; W G Walker
Journal:  Kidney Int       Date:  1974-09       Impact factor: 10.612

5.  Renal parenchymal accumulation of aminoglycoside antibiotics in rats.

Authors:  F C Luft; S A Kleit
Journal:  J Infect Dis       Date:  1974-12       Impact factor: 5.226

6.  Relationship between cephaloridine and p-aminohippurate transport in the kidney.

Authors:  B M Tune; M Fernholt
Journal:  Am J Physiol       Date:  1973-11

7.  Potentiation of gentamicin nephrotoxicity by metabolic acidosis.

Authors:  C H Hsu; T W Kurtz; R E Easterling; J M Weller
Journal:  Proc Soc Exp Biol Med       Date:  1974-07

8.  Effect of organic acid transport inhibitors on renal cortical uptake and proximal tubular toxicity of cephaloridine.

Authors:  B M Tune
Journal:  J Pharmacol Exp Ther       Date:  1972-05       Impact factor: 4.030

9.  Pharmacokinetics of gentamicin: distribution and plasma and renal clearance.

Authors:  A M Gyselynck; A Forrey; R Cutler
Journal:  J Infect Dis       Date:  1971-12       Impact factor: 5.226

10.  Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats.

Authors:  J Fabre; M Rudhardt; P Blanchard; C Regamey
Journal:  Kidney Int       Date:  1976-12       Impact factor: 10.612
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  3 in total

1.  Influence of single or multiple doses of gentamicin and netilmicin on their cortical, medullary, and papillary distribution.

Authors:  M G Bergeron; S Trottier
Journal:  Antimicrob Agents Chemother       Date:  1979-05       Impact factor: 5.191

2.  Determination of aminoglycosides in rat renal tissue by enzyme immunoassay.

Authors:  A P Provoost; W P Van Schalkwijk; O Adejuyigbe; W B Van Leeuwen; J H Wagenvoort
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

3.  Correlation between renal membrane binding and nephrotoxicity of aminoglycosides.

Authors:  P D Williams; D B Bennett; C R Gleason; G H Hottendorf
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191
  3 in total

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