OBJECTIVE: To assess frontal lobe functions of subjects with age-associated memory impairment (AAMI) and to examine whether performance on neuropsychological tests is correlated with the volume of the frontal lobes in magnetic resonance imaging. DESIGN: Cross-sectional two-group comparison. SETTING: The Memory Research Clinic of Kuopio University and the Magnetic Resonance Imaging Center of Kuopio University Hospital. PARTICIPANTS: Ninety subjects (mean age, 70.5 years), 43 with AAMI diagnosed according to National Institute of Mental Health criteria and 47 age-matched healthy controls. MEASUREMENTS: Four neuropsychological tests were used to assess frontal lobe function: Verbal Fluency Test (VFT), Modified Wisconsin Card Sorting Test (WCST), Trail Making Test (TMT), and Stroop Test (ST). A 1.5-T magnetic resonance imager was used for volume measurements. RESULTS: The AAMI subjects scored significantly worse on the WCST, ST, and TMT compared with controls (ANCOVA, adjusted for age and education, p < 0.05). The frontal lobe volumes did not differ between AAMI subjects and controls. CONCLUSIONS: AAMI subjects appear to be impaired not only in tests assessing memory but also in tests of executive functions. This finding agrees with previous reports suggesting a central role for frontal dysfunction in memory loss of elderly people.
OBJECTIVE: To assess frontal lobe functions of subjects with age-associated memory impairment (AAMI) and to examine whether performance on neuropsychological tests is correlated with the volume of the frontal lobes in magnetic resonance imaging. DESIGN: Cross-sectional two-group comparison. SETTING: The Memory Research Clinic of Kuopio University and the Magnetic Resonance Imaging Center of Kuopio University Hospital. PARTICIPANTS: Ninety subjects (mean age, 70.5 years), 43 with AAMI diagnosed according to National Institute of Mental Health criteria and 47 age-matched healthy controls. MEASUREMENTS: Four neuropsychological tests were used to assess frontal lobe function: Verbal Fluency Test (VFT), Modified Wisconsin Card Sorting Test (WCST), Trail Making Test (TMT), and Stroop Test (ST). A 1.5-T magnetic resonance imager was used for volume measurements. RESULTS: The AAMI subjects scored significantly worse on the WCST, ST, and TMT compared with controls (ANCOVA, adjusted for age and education, p < 0.05). The frontal lobe volumes did not differ between AAMI subjects and controls. CONCLUSIONS: AAMI subjects appear to be impaired not only in tests assessing memory but also in tests of executive functions. This finding agrees with previous reports suggesting a central role for frontal dysfunction in memory loss of elderly people.
Authors: Jordan F Karp; Charles F Reynolds; Meryl A Butters; Mary Amanda Dew; Sati Mazumdar; Amy E Begley; Eric Lenze; Debra K Weiner Journal: Pain Med Date: 2006 Sep-Oct Impact factor: 3.750
Authors: Lara H Heflin; Victor Laluz; Jung Jang; Robin Ketelle; Bruce L Miller; Joel H Kramer Journal: Neuropsychology Date: 2011-09 Impact factor: 3.295
Authors: O L Lopez; J T Becker; W J Jagust; A Fitzpatrick; M C Carlson; S T DeKosky; J Breitner; C G Lyketsos; B Jones; C Kawas; L H Kuller Journal: J Neurol Neurosurg Psychiatry Date: 2005-08-15 Impact factor: 10.154
Authors: J M Serra-Grabulosa; P Salgado-Pineda; C Junqué; C Solé-Padullés; P Moral; A López-Alomar; T López; A López-Guillén; N Bargalló; J M Mercader; I C Clemente; D Bartrés-Faz Journal: Neurogenetics Date: 2002-12-21 Impact factor: 2.660
Authors: Ethan A Winkler; John K Yue; Thomas W McAllister; Nancy R Temkin; Sam S Oh; Esteban G Burchard; Donglei Hu; Adam R Ferguson; Hester F Lingsma; John F Burke; Marco D Sorani; Jonathan Rosand; Esther L Yuh; Jason Barber; Phiroz E Tarapore; Raquel C Gardner; Sourabh Sharma; Gabriela G Satris; Celeste Eng; Ava M Puccio; Kevin K W Wang; Pratik Mukherjee; Alex B Valadka; David O Okonkwo; Ramon Diaz-Arrastia; Geoffrey T Manley Journal: Neurogenetics Date: 2015-11-17 Impact factor: 2.660