Literature DB >> 9007104

Loss of tuberin from cerebral tissues with tuberous sclerosis and astrocytoma.

M Mizuguchi1, M Kato, H Yamanouchi, K Ikeda, S Takashima.   

Abstract

We studied the expression of tuberin, the TSC2 gene product, in cerebra with or without tuberous sclerosis. Tuberin was abundant in the gray matter of normal cerebra, but was undetectable in the subependymal astrocytomas from 3 patients with tuberous sclerosis. In 1 patient, cortical tubers and normally appearing cortical tissue also showed a marked loss of tuberin. These results indicate the critical role of tuberin in the neuropathology of tuberous sclerosis.

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Year:  1996        PMID： 9007104     DOI： 10.1002/ana.410400621

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  5 in total

1.  Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs.

Authors:  Alan A Dombkowski; Carlos E Batista; Daniela Cukovic; Nicholas J Carruthers; Ramya Ranganathan; Upasana Shukla; Paul M Stemmer; Harry T Chugani; Diane C Chugani
Journal:  Cereb Cortex       Date:  2014-12-01       Impact factor: 5.357

2.  Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors.

Authors:  E P Henske; L L Wessner; J Golden; B W Scheithauer; A O Vortmeyer; Z Zhuang; A J Klein-Szanto; D J Kwiatkowski; R S Yeung
Journal:  Am J Pathol       Date:  1997-12       Impact factor: 4.307

3.  Biological behavior and tumorigenesis of subependymal giant cell astrocytomas.

Authors:  S K Kim; K C Wang; B K Cho; H W Jung; Y J Lee; Y S Chung; J Y Lee; S H Park; Y M Kim; G Choe; J G Chi
Journal:  J Neurooncol       Date:  2001-05       Impact factor: 4.130

4.  Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.

Authors:  June Goto; Delia M Talos; Peter Klein; Wei Qin; Yvonne I Chekaluk; Stefanie Anderl; Izabela A Malinowska; Alessia Di Nardo; Roderick T Bronson; Jennifer A Chan; Harry V Vinters; Steven G Kernie; Frances E Jensen; Mustafa Sahin; David J Kwiatkowski
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-24       Impact factor: 11.205

5.  Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas.

Authors:  Jiri Zavadil; Huihui Ye; Zhaojian Liu; JingJing Wu; Peng Lee; Eva Hernando; Patricia Soteropoulos; Gokce A Toruner; Jian-Jun Wei
Journal:  PLoS One       Date:  2010-08-24       Impact factor: 3.240
  5 in total

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