| Literature DB >> 9004288 |
T Chaly1, V Dhawan, K Kazumata, A Antonini, C Margouleff, J R Dahl, A Belakhlef, D Margouleff, A Yee, S Wang, G Tamagnan, J L Neumeyer, D Eidelberg.
Abstract
A procedure for the routine preparation of [18F]FP-CIT has been developed. Purification of the final product was achieved by preparative HPLC using phenethyl column without decomposition or epimerization. [18F] labeled-N-fluoropropyl-2 beta-carbomethoxy-3 beta-(4-iodophenyl) nortropane was prepared and PET imaging was performed on human subjects. A high uptake into striatal regions was observed. HPLC plasma analysis using [18F]FP-CIT indicated the presence of only one metabolite. By directly comparing the behavior of these three radiotracers ([18F]DOPA, [123I]FP-CIT, and [18F]FP-CIT) in the same subjects, we can enhance our understanding of the dopaminergic system as well as the relative potential of these techniques in a clinical research setting.Entities:
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Year: 1996 PMID： 9004288 DOI： 10.1016/s0969-8051(96)00155-2
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408