| Literature DB >> 9002940 |
A Zivelin1, J H Griffin, X Xu, I Pabinger, M Samama, J Conard, B Brenner, A Eldor, U Seligsohn.
Abstract
A common genetic risk factor for venous thrombosis among Caucasoid subpopulations is a polymorphism, nt G1691A, in blood coagulation factor V that replaces Arg506 with Gln and imparts resistance of factor Va to the anticoagulant, activated protein C. Haplotype analyses using six dimorphic sites in the factor V gene for 117 Caucasian subjects of Jewish, Arab, Austrian, and French origin who were homozygous for nt A1691 compared with 167 controls (nt G1691) support a single origin for this polymorphism. The nt G1691A mutation is estimated to have arisen circa 21,000 to 34,000 years ago, ie, after the evolutionary divergence of Africans from non-Africans and of Caucasoid from Mongoloid subpopulations.Entities:
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Year: 1997 PMID： 9002940
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113