Literature DB >> 9001394

Structure and distribution of a broadly expressed atypical sodium channel.

A N Akopian1, V Souslova, L Sivilotti, J N Wood.   

Abstract

A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

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Year:  1997        PMID： 9001394     DOI： 10.1016/s0014-5793(96)01389-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

Review 1.  The neuron as a dynamic electrogenic machine: modulation of sodium-channel expression as a basis for functional plasticity in neurons.

Authors:  S G Waxman
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2000-02-29       Impact factor: 6.237

2.  Immunolocalisation of sodium channel NaG in the intact and injured human peripheral nervous system.

Authors:  K Coward; A Mosahebi; C Plumpton; P Facer; R Birch; S Tate; C Bountra; G Terenghi; P Anand
Journal:  J Anat       Date:  2001-02       Impact factor: 2.610

3.  Nav2/NaG channel is involved in control of salt-intake behavior in the CNS.

Authors:  E Watanabe; A Fujikawa; H Matsunaga; Y Yasoshima; N Sako; T Yamamoto; C Saegusa; M Noda
Journal:  J Neurosci       Date:  2000-10-15       Impact factor: 6.167

Review 4.  Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects.

Authors:  J K J Diss; S P Fraser; M B A Djamgoz
Journal:  Eur Biophys J       Date:  2004-02-12       Impact factor: 1.733

Review 5.  The Nax (SCN7A) channel: an atypical regulator of tissue homeostasis and disease.

Authors:  David Dolivo; Adrian Rodrigues; Lauren Sun; Yingxing Li; Chun Hou; Robert Galiano; Seok Jong Hong; Thomas Mustoe
Journal:  Cell Mol Life Sci       Date:  2021-06-08       Impact factor: 9.261

6.  The sodium-activated sodium channel is expressed in the rat kidney thick ascending limb and collecting duct cells and is upregulated during high salt intake.

Authors:  Lucienne S Lara; Ryousuke Satou; Camille R T Bourgeois; Alexis A Gonzalez; Andrea Zsombok; Minolfa C Prieto; L Gabriel Navar
Journal:  Am J Physiol Renal Physiol       Date:  2012-03-21

7.  NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy.

Authors:  S D Dib-Hajj; L Tyrrell; J A Black; S G Waxman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-21       Impact factor: 11.205

8.  Channel properties of Nax expressed in neurons.

Authors:  Masahito Matsumoto; Takeshi Y Hiyama; Kazuya Kuboyama; Ryoko Suzuki; Akihiro Fujikawa; Masaharu Noda
Journal:  PLoS One       Date:  2015-05-11       Impact factor: 3.240

9.  The Expression Pattern of the Na(+) Sensor, Na(X) in the Hydromineral Homeostatic Network: A Comparative Study between the Rat and Mouse.

Authors:  Benjamin Nehmé; Mélaine Henry; Didier Mouginot; Guy Drolet
Journal:  Front Neuroanat       Date:  2012-07-19       Impact factor: 3.856

Review 10.  The roles of sodium channels in nociception: Implications for mechanisms of pain.

Authors:  Theodore R Cummins; Patrick L Sheets; Stephen G Waxman
Journal:  Pain       Date:  2007-09-04       Impact factor: 7.926
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