Literature DB >> 90012

Characterization of the WIDR: a human colon carcinoma cell line.

P Noguchi, R Wallace, J Johnson, E M Earley, S O'Brien, S Ferrone, M A Pellegrino, J Milstien, C Needy, W Browne, J Petricciani.   

Abstract

We describe the establishment and characterization of WiDr, a cell line derived from a human colon carcinoma. It produces carcinoembryonic antigen in culture, and has a doubling time of 15 hr with plating efficiency of 51%. The HLA antigenic profile and the allozyme genetic signature (composed of eight gene-enzyme systems) of WiDr cells are different from those of HeLa cells. Furthermore, WiDr cells possess three marker chromosomes, again distinct from the HeLa marker chromosomes. Finally, it is highly tumorigenic in four different xenogeneic animal models. Based on these studies, WiDr represents a useful model cell line for tumor cell biology investigations.

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Year:  1979        PMID： 90012     DOI： 10.1007/BF02618407

Source DB:  PubMed          Journal:  In Vitro        ISSN： 0073-5655


  30 in total

1.  Distinctive banded marker chromosomes of human tumor cell lines.

Authors:  W A Nelson-Rees; R R Flandermeyer; P K Hawthorne
Journal:  Int J Cancer       Date:  1975-07-15       Impact factor: 7.396

2.  Effect of antilymphocyte serum on the growth of Hep 2 and HeLa cells in mice.

Authors:  B Phillips; J C Gazet
Journal:  Nature       Date:  1968-12-14       Impact factor: 49.962

3.  A rapid method for direct HL-A typing of cultured lymphoid cells.

Authors:  S Ferrone; M A Pellegrino; R A Reisfeld
Journal:  J Immunol       Date:  1971-08       Impact factor: 5.422

4.  Enzyme polymorphisms as genetic signatures in human cell cultures.

Authors:  S U O'Brien; G Kleiner; R Olson; J E Shannon
Journal:  Science       Date:  1977-03-25       Impact factor: 47.728

5.  Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Authors:  J Fogh; W C Wright; J D Loveless
Journal:  J Natl Cancer Inst       Date:  1977-02       Impact factor: 13.506

6.  Safety of viral vaccine cell substrates: a reevaluation.

Authors:  J C Petricciani; J B Milstien; A S Seifried; R E Wallace; J B Johnson; D W McCoy
Journal:  J Natl Cancer Inst       Date:  1976-10       Impact factor: 13.506

7.  Heterotransplantation of cultured cell lines in newborn hamsters treated with antilymphocyte serum.

Authors:  R Wallace; P J Vasington; J C Petricciani
Journal:  Nature       Date:  1971-04-16       Impact factor: 49.962

8.  Classification of human colorectal adenocarcinoma cell lines.

Authors:  A Leibovitz; J C Stinson; W B McCombs; C E McCoy; K C Mazur; N D Mabry
Journal:  Cancer Res       Date:  1976-12       Impact factor: 12.701

9.  Human colonic adenocarcinoma cells. I. Establishment and description of a new line.

Authors:  B H Tom; L P Rutzky; M M Jakstys; R Oyasu; C I Kaye; B D Kahan
Journal:  In Vitro       Date:  1976-03

10.  Heterotransplantation of human malignant tumors in "nude" thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human solid tumors.

Authors:  B C Giovanella; J S Stehlin; L J Williams
Journal:  J Natl Cancer Inst       Date:  1974-03       Impact factor: 13.506
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  40 in total

1.  Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy.

Authors:  Asta Juzeniene; Petras Juzenas; Li-Wei Ma; Vladimir Iani; Johan Moan
Journal:  Lasers Med Sci       Date:  2004-10-16       Impact factor: 3.161

2.  Role of soluble factors and three-dimensional culture in in vitro differentiation of intestinal macrophages.

Authors:  Tanja Spoettl; Martin Hausmann; Katrin Menzel; Heidi Piberger; Hans Herfarth; Juergen Schoelmerich; Frauke Bataille; Gerhard Rogler
Journal:  World J Gastroenterol       Date:  2007-02-21       Impact factor: 5.742

3.  Cyclic AMP-dependent Cl- secretion induced by thromboxane A2 in isolated human colon.

Authors:  Naoki Horikawa; Tomoyuki Suzuki; Takaoki Uchiumi; Tetsuji Minamimura; Kazuhiro Tsukada; Noriaki Takeguchi; Hideki Sakai
Journal:  J Physiol       Date:  2004-12-20       Impact factor: 5.182

4.  Cell-to-cell contact as an efficient mode of Epstein-Barr virus infection of diverse human epithelial cells.

Authors:  S Imai; J Nishikawa; K Takada
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

5.  Intracellular adenosine triphosphate as a measure of human tumor cell viability and drug modulated growth.

Authors:  F R Ahmann; H S Garewal; R Schifman; A Celniker; S Rodney
Journal:  In Vitro Cell Dev Biol       Date:  1987-07

6.  Human muscle: a model for the study of human neoplasia.

Authors:  J C Petricciani; I Levenbook; R Locke
Journal:  Invest New Drugs       Date:  1983       Impact factor: 3.850

7.  Characterization of a human colonic adenocarcinoma cell line, LS123.

Authors:  L P Rutzky; B C Giovanella; B H Tom; C I Kaye; P D Noguchi; B D Kahan
Journal:  In Vitro       Date:  1983-02

8.  The PIT method: an automated in vitro technique for drug toxicity testing.

Authors:  R van Lambalgen; P Lelieveld
Journal:  Invest New Drugs       Date:  1987       Impact factor: 3.850

9.  Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice.

Authors:  S Apasov; M Sitkovsky
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

10.  p53 mutations in flat- and polypoid-type colorectal tumors detected by temperature-gradient gel electrophoresis.

Authors:  Y Yamamura-Idei; K Satonaka; T Fujimori; S Maeda; T Chiba
Journal:  Dig Dis Sci       Date:  1994-09       Impact factor: 3.199
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