Literature DB >> 9001142

In vivo 23Na NMR studies of myotonic dystrophy.

T Kushnir1, T Knubovets, Y Itzchak, U Eliav, M Sadeh, L Rapoport, E Kott, G Navon.   

Abstract

Myotonic dystrophy is an inherited multi-system disease. Its pathophysiology leading to muscle malfunction and damage is not well understood. 23Na NMR spectroscopy was applied here for an in vivo comparative study of the calf muscles of 7 myotonic dystrophy patients at various stages of the disease and 11 healthy volunteers. Both the total sodium content, expressed as the ratio of the 23Na and 1H water signals, and the fast transverse relaxation time, T2f, determined from the triple quantum-filtered spectra, increased in correlation with the severity of the disease. The results demonstrate that 23Na NMR enables the quantitation of myotonic dystrophy progression.

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Year:  1997        PMID： 9001142     DOI： 10.1002/mrm.1910370209

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  9 in total

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