Literature DB >> 9000889

Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.

K Hu1, A Dong, X Yao, H Kobayashi, S Iwasaki.   

Abstract

By activity-guided fractionation, three known steroidal saponins, prosapogenin A of dioscin, dioscin and gracillin, were isolated from the total saponin fraction of Dioscorea coiletti var. hypoglauca as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. The compounds also exhibited cytotoxic activity against the cancer cell line K562 in vitro. The structures of the compounds were elucidated on the basis of chemical evidence and IR, FAB-MS, 1H-NMR, 13C-NMR, and two-dimensional NMR (2D-NMR) analysis.

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Year:  1996        PMID： 9000889     DOI： 10.1055/s-2006-957978

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  Functional properties of autolysate and enzymatic hydrolysates from yam tsukuneimo (Dioscorea opposita Thunb.) tuber mucilage tororo: antioxidative activity and antihypertensive activity.

Authors:  Takeshi Nagai; Nobutaka Suzuki; Norihisa Kai; Yasuhiro Tanoue
Journal:  J Food Sci Technol       Date:  2012-12-20       Impact factor: 2.701

2.  Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC-ELSD.

Authors:  Bharathi Avula; Yan-Hong Wang; Zulfiqar Ali; Troy J Smillie; Ikhlas A Khan
Journal:  Biomed Chromatogr       Date:  2013-09-10       Impact factor: 1.902

3.  Preparation of progenin III from total steroidal saponins of Dioscorea nipponica Makino using a crude enzyme from Aspergillus oryzae strain.

Authors:  Tingqiang Liu; Hongshan Yu; Chunying Liu; Yongming Bao; Xiangchun Hu; Yuanhao Wang; Bing Liu; Yaoyao Fu; Sihui Tang; Fengxie Jin
Journal:  J Ind Microbiol Biotechnol       Date:  2013-03-08       Impact factor: 3.346

4.  Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.

Authors:  Zulfiqar Ali; Troy J Smillie; Ikhlas A Khan
Journal:  Nat Prod Commun       Date:  2013-03       Impact factor: 0.986

5.  Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells.

Authors:  Toshiko Suzuki-Yamamoto; Sayuri Tanaka; Izumi Tsukayama; Miki Takafuji; Takae Hanada; Toshiya Arakawa; Yuki Kawakami; Masumi Kimoto; Yoshitaka Takahashi
Journal:  J Clin Biochem Nutr       Date:  2014-09-09       Impact factor: 3.114

Review 6.  The Dioscorea Genus (Yam)-An Appraisal of Nutritional and Therapeutic Potentials.

Authors:  Jude E Obidiegwu; Jessica B Lyons; Cynthia A Chilaka
Journal:  Foods       Date:  2020-09-16
  6 in total

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