Influence of aspirin on the contingent negative wave in healthy subjects.

A study was made of the alterations of the parameters of the slow brain potential, the contingent negative wave, under the influence of aspirin in healthy individuals, using the double blind method. The early and late wave of the CNW were investigated. A statistically significant decrease in the early CN wave was obtained after the ingestion of aspirin, and an increase in the late wave after the ingestion of aspirin and placebo. A central effect of aspirin, affecting the noradrenergic and dopaminergic brain systems, is hypothesized to explain the changes described.

RCT Entities:   Population Interventions Outcomes