Long-term changes in the efficiency of inhibitory transmission in the thalamocortical neuronal networks induced by microstimulation of the cortex.

Long-term potentiation (LTP) and long-term depression (LTD) of the efficiency of inhibitory transmission between different elements of a network took place in neuronal networks consisting of AC and MGB cells, as a result of MS of the cortex. LTP of inhibition was an input-specific effect, since it could develop simultaneously with LTP of the efficiency of excitatory transmission to the same cell and do not lead to a decrease in its baseline frequency. LTP (LTD) of inhibition was observed simultaneously with an increase (decrease) in the frequency of baseline impulse activity of the inhibitory neuron or neuron which is presynaptic in relation to an inhibitory neuron; the efficiency of the synaptic effect of one inhibitory neuron on various postsynaptic cells could vary in different directions. The data obtained may suggest the participation of both pre- and postsynaptic mechanisms in the modification of the efficiency of inhibition.