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Literature DB >> 8997453

Reactive oxygen species and the neurodegenerative disorders.

Abstract

The major neurodegenerative disorders include Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and multiple sclerosis. Although their etiology and pathogenesis are unknown, numerous recent studies suggest that oxygen-derived free radicals play an important role. Furthermore, these reactive oxygen species are probably important in brain ischemia and reperfusion, Down's syndrome, and the mitochondrial encephalopathies. In this review, evidence for oxygen-derived free radicals in the pathogenesis of these disorders is discussed.

Entities: Chemical Disease

Mesh：

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Year: 1997 PMID： 8997453

Source DB: PubMed Journal: Ann Clin Lab Sci ISSN： 0091-7370 Impact factor: 1.256

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Cited

19 in total

Review 1. NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance.

Authors: V Calabrese; T E Bates; A M Stella
Journal: Neurochem Res Date: 2000-10 Impact factor: 3.996

2. D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.

Authors: Jin-Miao Lu; Nian Gong; Yan-Chao Wang; Yong-Xiang Wang
Journal: Br J Pharmacol Date: 2012-03 Impact factor: 8.739

3. Primary involvement of NADPH oxidase 4 in hypoxia-induced generation of reactive oxygen species in adipose-derived stem cells.

Authors: Ji Hye Kim; Seung-Yong Song; Sang Gyu Park; Sun U Song; Ying Xia; Jong-Hyuk Sung
Journal: Stem Cells Dev Date: 2012-02-03 Impact factor: 3.272

10. A novel oral nutraceutical formula of omega-3 and omega-6 fatty acids with vitamins (PLP10) in relapsing remitting multiple sclerosis: a randomised, double-blind, placebo-controlled proof-of-concept clinical trial.

Authors: Marios C Pantzaris; George N Loukaides; Evangelia E Ntzani; Ioannis S Patrikios
Journal: BMJ Open Date: 2013-04-17 Impact factor: 2.692

Reactive oxygen species and the neurodegenerative disorders.

Review 1. NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance.

2. D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.

3. Primary involvement of NADPH oxidase 4 in hypoxia-induced generation of reactive oxygen species in adipose-derived stem cells.

4. Necrosis and apoptosis in lymphoma cell lines exposed to eicosapentaenoic acid and antioxidants.

Review 5. Oxidative stress, nitric oxide, and diabetes.

6. Neuregulin induces sustained reactive oxygen species generation to mediate neuronal differentiation.

7. Protective role of oral antioxidant supplementation in ocular surface of diabetic patients.

8. Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats.

Review 9. 2D phosphorene nanosheets, quantum dots, nanoribbons: synthesis and biomedical applications.

10. A novel oral nutraceutical formula of omega-3 and omega-6 fatty acids with vitamins (PLP10) in relapsing remitting multiple sclerosis: a randomised, double-blind, placebo-controlled proof-of-concept clinical trial.