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Literature DB >> 899740

Clofibrate-induced myopathy in the rat.

Abstract

Rats were given daily injections of 0.2 or 0.5 g/kg chlorophenoxyisobutyrate (clofibrate) for 9 to 46 days. Lower leg muscles were studied with light and electron microscopy. Daily treatment with 0.5 g/kg of the drug for 26--46 days caused myopathic changes.

Entities: Chemical Disease Species

Mesh：

Substances：
Clofibrate

Year: 1977 PMID： 899740 DOI： 10.1007/bf00703319

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

13 in total

1. Clofibrate, nephrotic syndrome, and histological changes in muscle.

Authors: M Denizot; J Fabre; D Pometta; E Wildi
Journal: Lancet Date: 1973-06-09 Impact factor: 79.321

2. Procedure for the histochemical demonstration of actomyosin ATPase.

Authors: L Guth; F J Samaha
Journal: Exp Neurol Date: 1970-08 Impact factor: 5.330

3. Muscular syndrome after clofibrate.

Authors: N Katsilambros; J Braaten; B D Ferguson; R F Bradley
Journal: N Engl J Med Date: 1972-05-18 Impact factor: 91.245

4. Acute muscular syndrome associated with administration of clofibrate.

Authors: T Langer; R I Levy
Journal: N Engl J Med Date: 1968-10-17 Impact factor: 91.245

5. Clofibrate-induced muscle damage in patients with chronic renal failure.

Authors: A M Pierides; F Alvarez-Ude; D N Kerr
Journal: Lancet Date: 1975-12-27 Impact factor: 79.321

6. Mode of inhibition of mitochondrial energy transduction by chlorophenoxyisobutyrate.

Authors: S R Panini; C K Kurup
Journal: Biochem J Date: 1974-08 Impact factor: 3.857

7. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.

Authors: E S REYNOLDS
Journal: J Cell Biol Date: 1963-04 Impact factor: 10.539

8. Improvements in epoxy resin embedding methods.

Authors: J H LUFT
Journal: J Biophys Biochem Cytol Date: 1961-02

9. Staining of tissue sections for electron microscopy with heavy metals.

Authors: M L WATSON
Journal: J Biophys Biochem Cytol Date: 1958-07-25

10. Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.

Authors: D D SABATINI; K BENSCH; R J BARRNETT
Journal: J Cell Biol Date: 1963-04 Impact factor: 10.539

10 in total

Review 1. Clinical features, pathogenesis and management of drug-induced rhabdomyolysis.

Authors: C Köppel
Journal: Med Toxicol Adverse Drug Exp Date: 1989 Mar-Apr

Review 2. Bezafibrate induced rhabdomyolysis.

Authors: E Kanterewicz; R Sanmartí; J Riba; I Trias; J Autonell; J Brugués
Journal: Ann Rheum Dis Date: 1992-04 Impact factor: 19.103

3. Mitochondrial myopathy--a result of clofibrate/etofibrate treatment? Case report.

Authors: A Bardosi; P Scheidt; H H Goebel
Journal: Acta Neuropathol Date: 1985 Impact factor: 17.088

4. Clofibrate-induced myotonia in the rat.

Authors: A Eberstein; J Goodgold; R Johnston
Journal: Experientia Date: 1978-12-15

5. Effects of clofibric acid on the activity and activity state of the hepatic branched-chain 2-oxo acid dehydrogenase complex.

Authors: Y Zhao; J Jaskiewicz; R A Harris
Journal: Biochem J Date: 1992-07-01 Impact factor: 3.857

Review 6. Adverse effects of drugs on muscle.

Authors: F L Mastaglia
Journal: Drugs Date: 1982-10 Impact factor: 9.546

10. Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.

Authors: S Levak-Frank; H Radner; A Walsh; R Stollberger; G Knipping; G Hoefler; W Sattler; P H Weinstock; J L Breslow; R Zechner
Journal: J Clin Invest Date: 1995-08 Impact factor: 14.808