Literature DB >> 8996544

BRCA1 mutations and phenotype.

K Grade1, K Höffken, R Kath, A Nothnagel, E Bender, S Scherneck.   

Abstract

More than 100 mutations have been described for the breast-cancer-susceptibility gene BRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative gene product, combined with greater severity of the disease.

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Mesh：

Year:  1997        PMID： 8996544     DOI： 10.1007/bf01212618

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  12 in total

1.  Does this have a familiar RING?

Authors:  A J Saurin; K L Borden; M N Boddy; P S Freemont
Journal:  Trends Biochem Sci       Date:  1996-06       Impact factor: 13.807

2.  BRCA1 mutation update and analysis.

Authors:  K Grade; B Jandrig; S Scherneck
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

3.  A novel mutation in the BRCA1 gene in a German early-onset breast cancer family.

Authors:  B Waindzoch; K Grade; B Jandrig; M Müller; P Schlag; S Scherneck
Journal:  Hum Mutat       Date:  1996       Impact factor: 4.878

4.  Familial breast-ovarian cancer locus on chromosome 17q12-q23.

Authors:  S A Narod; J Feunteun; H T Lynch; P Watson; T Conway; J Lynch; G M Lenoir
Journal:  Lancet       Date:  1991-07-13       Impact factor: 79.321

5.  Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

Authors:  R Wooster; S L Neuhausen; J Mangion; Y Quirk; D Ford; N Collins; K Nguyen; S Seal; T Tran; D Averill
Journal:  Science       Date:  1994-09-30       Impact factor: 47.728

6.  Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. Breast Cancer Information Core.

Authors:  F J Couch; B L Weber
Journal:  Hum Mutat       Date:  1996       Impact factor: 4.878

7.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Authors:  Y Miki; J Swensen; D Shattuck-Eidens; P A Futreal; K Harshman; S Tavtigian; Q Liu; C Cochran; L M Bennett; W Ding
Journal:  Science       Date:  1994-10-07       Impact factor: 47.728

8.  Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families.

Authors:  L S Friedman; E A Ostermeyer; C I Szabo; P Dowd; E D Lynch; S E Rowell; M C King
Journal:  Nat Genet       Date:  1994-12       Impact factor: 38.330

9.  Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families.

Authors:  J Simard; P Tonin; F Durocher; K Morgan; J Rommens; S Gingras; C Samson; J F Leblanc; C Bélanger; F Dion
Journal:  Nat Genet       Date:  1994-12       Impact factor: 38.330

10.  Growth retardation and tumour inhibition by BRCA1.

Authors:  J T Holt; M E Thompson; C Szabo; C Robinson-Benion; C L Arteaga; M C King; R A Jensen
Journal:  Nat Genet       Date:  1996-03       Impact factor: 38.330
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  1 in total

Review 1.  BRCA1 and BRCA2 proteins: roles in health and disease.

Authors:  J A Duncan; J R Reeves; T G Cooke
Journal:  Mol Pathol       Date:  1998-10
  1 in total

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