L E Smeele1, P J Kostense, I van der Waal, G B Snow. 1. Department of Oral and Maxillofacial Surgery and Oral Pathology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands. pathol@azvu.nl
Abstract
PURPOSE: To evaluate the possible value of chemotherapy in the treatment of craniofacial osteosarcoma (CFOS). DESIGN: In a systematic review, data of 201 patients (age, 36.6 +/- 19.0 years [mean +/- SD]) from 20 uncontrolled series on CFOS indexed in Medline and Excerpta Medica between 1974 and 1994 were pooled; 180 patients had undergone surgery. Various chemotherapy regimens had been given to 71 patients. Radiotherapy was used in 69 patients. All patients had data for overall survival, and 182 had data for disease-free survival analysis. Cumulative survival distributions were estimated by the product-limit method, and a multiple regression analysis was performed. RESULTS: Patients' overall and disease-free survival rates were significantly improved by treatment with chemotherapy. This was confirmed for patients with complete surgical removal, as well as for those with incomplete removal of tumor. In a proportional hazards model, complete surgical removal and chemotherapy were independent significant factors for overall and disease-free survival. The effect of radiotherapy was insignificant. No prognostic factors could be identified among age groups, sex, and subsites. CONCLUSION: Evidence exists that chemotherapy improves survival in CFOS. We advocate the adoption of the chemotherapy protocols used for OS of the long bones for CFOS.
PURPOSE: To evaluate the possible value of chemotherapy in the treatment of craniofacial osteosarcoma (CFOS). DESIGN: In a systematic review, data of 201 patients (age, 36.6 +/- 19.0 years [mean +/- SD]) from 20 uncontrolled series on CFOS indexed in Medline and Excerpta Medica between 1974 and 1994 were pooled; 180 patients had undergone surgery. Various chemotherapy regimens had been given to 71 patients. Radiotherapy was used in 69 patients. All patients had data for overall survival, and 182 had data for disease-free survival analysis. Cumulative survival distributions were estimated by the product-limit method, and a multiple regression analysis was performed. RESULTS:Patients' overall and disease-free survival rates were significantly improved by treatment with chemotherapy. This was confirmed for patients with complete surgical removal, as well as for those with incomplete removal of tumor. In a proportional hazards model, complete surgical removal and chemotherapy were independent significant factors for overall and disease-free survival. The effect of radiotherapy was insignificant. No prognostic factors could be identified among age groups, sex, and subsites. CONCLUSION: Evidence exists that chemotherapy improves survival in CFOS. We advocate the adoption of the chemotherapy protocols used for OS of the long bones for CFOS.
Authors: Daris Ferrari; Carla Codecà; Nicolò Battisti; Francesca Broggio; Francesca Crepaldi; Martina Violati; Cecilia Bertuzzi; Lorenzo Dottorini; Sarah Caldiera; Andrea Luciani; Laura Moneghini; Federico Biglioli; Gabriela Cassinelli; Alberto Morabito; Paolo Foa Journal: Med Oncol Date: 2014-08-19 Impact factor: 3.064
Authors: C Kumaravelu; D Sathya Kumar; Chitra Chakravarthy; R V Kishore Kumar; Gali Rajasekhar; M Gokul Chandra Reddy; K Sridhar Reddy Journal: J Maxillofac Oral Surg Date: 2009-11-21
Authors: Thomas Mücke; David A Mitchell; Andrea Tannapfel; Klaus-Dietrich Wolff; Denys John Loeffelbein; Anastasios Kanatas Journal: J Cancer Res Clin Oncol Date: 2013-11-26 Impact factor: 4.553