Literature DB >> 8995526

p53 Phosphorylation: biochemical and functional consequences.

G J Milczarek1, J Martinez, G T Bowden.   

Abstract

The p53 protein plays a vital role in suppressing the development of cancer. Posttranslational modification through phosphorylation has been postulated to be an important regulatory mechanism of p53 function. Data describing the role of phosphorylation in terms of its effects on several biochemical properties and cellular functions of p53 are examined in the context of how p53 might be "phospho-regulated."

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Year:  1997        PMID： 8995526     DOI： 10.1016/s0024-3205(96)00479-1

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  19 in total

1.  Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

Authors:  T Unger; T Juven-Gershon; E Moallem; M Berger; R Vogt Sionov; G Lozano; M Oren; Y Haupt
Journal:  EMBO J       Date:  1999-04-01       Impact factor: 11.598

2.  Protein kinase C-dependent phosphorylation regulates the cell cycle-inhibitory function of the p73 carboxy terminus transactivation domain.

Authors:  Ulrika Nyman; Pinelopi Vlachos; Anna Cascante; Ola Hermanson; Boris Zhivotovsky; Bertrand Joseph
Journal:  Mol Cell Biol       Date:  2009-01-21       Impact factor: 4.272

3.  Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.

Authors:  Yuan Shen; Shanshan Liu; Jiao Fan; Yinghua Jin; Baolei Tian; Xiaofei Zheng; Hanjiang Fu
Journal:  EMBO Rep       Date:  2017-03-06       Impact factor: 8.807

4.  Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.

Authors:  Zorica Janjetovic; Zachary P Nahmias; Sherie Hanna; Stuart G Jarrett; Tae-Kang Kim; Russel J Reiter; Adrzej T Slominski
Journal:  J Pineal Res       Date:  2014-06-28       Impact factor: 13.007

Review 5.  Posttranslational phosphorylation of mutant p53 protein in tumor development.

Authors:  Manabu Matsumoto; Mutsuo Furihata; Yuji Ohtsuki
Journal:  Med Mol Morphol       Date:  2006-06       Impact factor: 2.309

Review 6.  p53 and the CNS: tumors and developmental abnormalities.

Authors:  G Fulci; E G Van Meir
Journal:  Mol Neurobiol       Date:  1999-02       Impact factor: 5.590

7.  Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene.

Authors:  D Bagchi; M Bagchi; S J Stohs
Journal:  Mol Cell Biochem       Date:  2001-06       Impact factor: 3.396

8.  Regulation of p53 function and stability by phosphorylation.

Authors:  M Ashcroft; M H Kubbutat; K H Vousden
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

Review 9.  Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.

Authors:  Andrzej T Slominski; Zorica Janjetovic; Tae-Kang Kim; Piotr Wasilewski; Sofia Rosas; Sherie Hanna; Robert M Sayre; John C Dowdy; Wei Li; Robert C Tuckey
Journal:  J Steroid Biochem Mol Biol       Date:  2015-01-21       Impact factor: 4.292

10.  p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation.

Authors:  J Xu; G F Morris
Journal:  Mol Cell Biol       Date:  1999-01       Impact factor: 4.272
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