Definitive radiation management for carcinoma of the glottic larynx.

Radiation therapy offers excellent cure rates and preservation of the larynx in the majority of early-stage glottic cancers. Outcome may vary because of patient-, tumor-, and treatment-related variables. Carefully selected advanced lesions may also be successfully managed with irradiation. Hyperfractionation and combined chemotherapy-radiotherapy protocols seem to be promising strategies for the improvement of the therapeutic ratio in treatment of patients with more advanced lesions.