Literature DB >> 8994964

Precluding uracil from DNA.

D G Vassylyev1, K Morikawa.   

Abstract

Two enzymes, dUTP pyrophosphatase and uracil-DNA glycosylase, prevent the misincorporation of uracil into the genome in distinct manners. The atomic structures of these proteins complexed with substrate analogs reveal the structural basis for uracil recognition and suggest a novel mechanism of DNA repair.

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Year:  1996        PMID： 8994964     DOI： 10.1016/s0969-2126(96)00145-1

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  5 in total

1.  Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

Authors:  S S Parikh; C D Mol; G Slupphaug; S Bharati; H E Krokan; J A Tainer
Journal:  EMBO J       Date:  1998-09-01       Impact factor: 11.598

2.  Predicting protein-DNA interactions by full search computational docking.

Authors:  Victoria A Roberts; Michael E Pique; Lynn F Ten Eyck; Sheng Li
Journal:  Proteins       Date:  2013-10-18

3.  Presence of dUTPase in the various human endogenous retrovirus K (HERV-K) families.

Authors:  Jens Mayer; Eckart U Meese
Journal:  J Mol Evol       Date:  2003-12       Impact factor: 2.395

4.  Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.

Authors:  Victoria A Roberts; Michael E Pique; Simon Hsu; Sheng Li; Geir Slupphaug; Robert P Rambo; Jonathan W Jamison; Tong Liu; Jun H Lee; John A Tainer; Lynn F Ten Eyck; Virgil L Woods
Journal:  Nucleic Acids Res       Date:  2012-04-06       Impact factor: 16.971

Review 5.  Gene Therapy Applications of Non-Human Lentiviral Vectors.

Authors:  Altar M Munis
Journal:  Viruses       Date:  2020-09-29       Impact factor: 5.048
  5 in total

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