Literature DB >> 8994883

New structures of allosteric proteins revealing remarkable conformational changes.

A Mattevi1, M Rizzi, M Bolognesi.   

Abstract

New three-dimensional structures of allosteric proteins reveal they have a flexible architecture that is instrumental to the regulation of protein function. Highlights are the structures of GroEL, pyruvate kinase, D-3-phosphoglycerate dehydrogenase and the acetylcholine receptor. Furthermore, significant progress in understanding the nature of the intermediates involved in an allosteric reaction has been achieved through recent spectroscopic and crystallographic studies on haemoglobin.

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Year:  1996        PMID： 8994883     DOI： 10.1016/s0959-440x(96)80013-3

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  7 in total

1.  Modeling the kinetics of acylation of insulin using a recursive method for solving the systems of coupled differential equations.

Authors:  B A Grzybowski; J R Anderson; I Colton; S T Brittain; E I Shakhnovich; G M Whitesides
Journal:  Biophys J       Date:  2000-02       Impact factor: 4.033

Review 2.  Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations.

Authors:  Buyong Ma; Maxim Shatsky; Haim J Wolfson; Ruth Nussinov
Journal:  Protein Sci       Date:  2002-02       Impact factor: 6.725

Review 3.  Archaeal protein kinases and protein phosphatases: insights from genomics and biochemistry.

Authors:  Peter J Kennelly
Journal:  Biochem J       Date:  2003-03-01       Impact factor: 3.857

4.  Conformational Dynamics and Allostery in Pyruvate Kinase.

Authors:  Katherine A Donovan; Shaolong Zhu; Peter Liuni; Fen Peng; Sarah A Kessans; Derek J Wilson; Renwick C J Dobson
Journal:  J Biol Chem       Date:  2016-02-15       Impact factor: 5.157

5.  Simultaneous analysis of enzyme structure and activity by kinetic capillary electrophoresis-MS.

Authors:  Gleb G Mironov; Christopher M Clouthier; Abdullah Akbar; Jeffrey W Keillor; Maxim V Berezovski
Journal:  Nat Chem Biol       Date:  2016-09-05       Impact factor: 15.040

6.  Target flexibility: an emerging consideration in drug discovery and design.

Authors:  Pietro Cozzini; Glen E Kellogg; Francesca Spyrakis; Donald J Abraham; Gabriele Costantino; Andrew Emerson; Francesca Fanelli; Holger Gohlke; Leslie A Kuhn; Garrett M Morris; Modesto Orozco; Thelma A Pertinhez; Menico Rizzi; Christoph A Sotriffer
Journal:  J Med Chem       Date:  2008-09-12       Impact factor: 7.446

7.  Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

Authors:  Taro Hitosugi; Sumin Kang; Matthew G Vander Heiden; Tae-Wook Chung; Shannon Elf; Katherine Lythgoe; Shaozhong Dong; Sagar Lonial; Xu Wang; Georgia Z Chen; Jianxin Xie; Ting-Lei Gu; Roberto D Polakiewicz; Johannes L Roesel; Titus J Boggon; Fadlo R Khuri; D Gary Gilliland; Lewis C Cantley; Jonathan Kaufman; Jing Chen
Journal:  Sci Signal       Date:  2009-11-17       Impact factor: 8.192
  7 in total

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