Literature DB >> 8994864

Manipulation of the Th1/Th2 balance in autoimmune disease.

L B Nicholson1, V K Kuchroo.   

Abstract

Many autoimmune diseases are caused by autopathogenic Th1 cells. Because in vitro Th1 and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific Th2 cells can prevent autoimmune disease. In the past year, investigators have further defined the role of Th1 and Th2 cytokines in the induction and regulation of autoimmunity. Furthermore, the role of MHC-antigen-T-cell avidity (strength of signal) in inducing such protective immune responses has been elucidated.

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Year:  1996        PMID： 8994864     DOI： 10.1016/s0952-7915(96)80013-6

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  48 in total

1.  Host resistance against Candida alibcans infection in mice with adjuvant induced arthritis.

Authors:  Martin Yordanov; Anna Deleva; Nina Ivanovska
Journal:  Mycopathologia       Date:  2002       Impact factor: 2.574

2.  Identification of Th2-type suppressor T cells among in vivo expanded ocular T cells in mice with experimental autoimmune uveoretinitis.

Authors:  H Keino; M Takeuchi; J Suzuki; S Kojo; J Sakai; K Nishioka; T Sumida; M Usui
Journal:  Clin Exp Immunol       Date:  2001-04       Impact factor: 4.330

3.  Autoantigen-specific protection of non-obese diabetic mice from cyclophosphamide-accelerated diabetes by vaccination with dendritic cells.

Authors:  T Krueger; U Wohlrab; M Klucken; M Schott; J Seissler
Journal:  Diabetologia       Date:  2003-08-20       Impact factor: 10.122

4.  Molecular mechanisms in Behçet's disease.

Authors:  R Rajendram; N A Rao
Journal:  Br J Ophthalmol       Date:  2003-10       Impact factor: 4.638

5.  GAD65 antibody isotypes and epitope recognition during the prediabetic process in siblings of children with type I diabetes.

Authors:  S Hoppu; M S Ronkainen; P Kulmala; H K Akerblom; M Knip
Journal:  Clin Exp Immunol       Date:  2004-04       Impact factor: 4.330

6.  Cytokine profile in the liver of primary biliary cirrhosis.

Authors:  T Nagano; K Yamamoto; S Matsumoto; R Okamoto; M Tagashira; N Ibuki; S Matsumura; K Yabushita; N Okano; T Tsuji
Journal:  J Clin Immunol       Date:  1999-11       Impact factor: 8.317

7.  IgG subclass reactivity to human cardiac myosin in cardiomyopathy patients is indicative of a Th1-like autoimmune disease.

Authors:  P Skyllouriotis; M Skyllouriotis-Lazarou; S Natter; R Steiner; S Spitzauer; S Kapiotis; P Valent; A M Hirschl; S E Guber; G Laufer; G Wollenek; E Wolner; M Wimmer; R Valenta
Journal:  Clin Exp Immunol       Date:  1999-02       Impact factor: 4.330

8.  Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors.

Authors:  Hozefa S Bandukwala; John Gagnon; Susan Togher; Jason A Greenbaum; Edward D Lamperti; Nigel J Parr; Amy M H Molesworth; Nicholas Smithers; Kevin Lee; Jason Witherington; David F Tough; Rab K Prinjha; Bjoern Peters; Anjana Rao
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-21       Impact factor: 11.205

9.  CD86 (B7-2), but not CD80 (B7-1), expression in the epidermis of transgenic mice enhances the immunogenicity of primary cutaneous Candida albicans infections.

Authors:  A A Gaspari; R Burns; A Nasir; D Ramirez; R K Barth; C G Haidaris
Journal:  Infect Immun       Date:  1998-09       Impact factor: 3.441

Review 10.  APC-derived cytokines and T cell polarization in autoimmune inflammation.

Authors:  Ilona Gutcher; Burkhard Becher
Journal:  J Clin Invest       Date:  2007-05       Impact factor: 14.808
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