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Literature DB >> 8994839

Genome research and evolution in trypanosomes.

Abstract

Trypanosoma brucei and Trypanosoma cruzi cause different human diseases. As strategies for immune evasion, T. brucei undergone antigenic variation whereas T. cruzi becomes an intracellular organism. This fundamental difference is reflected by major differences in their genome organizations. Recent comparisons of their gene sequences indicate that these two trypanosome species are highly divergent evolutionarily.

Entities: Disease Species

Mesh：

Substances：
RNA, Protozoan

Year: 1996 PMID： 8994839 DOI： 10.1016/s0959-437x(96)80023-2

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

6 in total

1. Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes.

Authors: D J LaCount; N M El-Sayed; S Kaul; D Wanless; C M Turner; J E Donelson
Journal: Nucleic Acids Res Date: 2001-05-15 Impact factor: 16.971

2. The L1Tc C-terminal domain from Trypanosoma cruzi non-long terminal repeat retrotransposon codes for a protein that bears two C2H2 zinc finger motifs and is endowed with nucleic acid chaperone activity.

Authors: Sara R Heras; Manuel C López; José Luis García-Pérez; Sandra L Martin; M Carmen Thomas
Journal: Mol Cell Biol Date: 2005-11 Impact factor: 4.272

6. The L1Tc non-LTR retrotransposon of Trypanosoma cruzi contains an internal RNA-pol II-dependent promoter that strongly activates gene transcription and generates unspliced transcripts.

Authors: Sara R Heras; Manuel C López; Mónica Olivares; M Carmen Thomas
Journal: Nucleic Acids Res Date: 2007-03-16 Impact factor: 16.971

6 in total

Genome research and evolution in trypanosomes.

1. Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes.

2. The L1Tc C-terminal domain from Trypanosoma cruzi non-long terminal repeat retrotransposon codes for a protein that bears two C2H2 zinc finger motifs and is endowed with nucleic acid chaperone activity.

3. Nucleic-acid-binding properties of the C2-L1Tc nucleic acid chaperone encoded by L1Tc retrotransposon.

4. alpha5 subunit in Trypanosoma brucei proteasome can self-assemble to form a cylinder of four stacked heptamer rings.

5. Import and assembly of Neurospora crassa Tom40 into mitochondria of Trypanosoma brucei in vivo.

6. The L1Tc non-LTR retrotransposon of Trypanosoma cruzi contains an internal RNA-pol II-dependent promoter that strongly activates gene transcription and generates unspliced transcripts.