Literature DB >> 8994811

HIV-1: is Nef a PAK animal?

B R Cullen1.   

Abstract

HIV-1 Nef is clearly essential for efficient viral replication in vivo, but it has been difficult to determine why. Recent evidence that Nef specifically activates a PAK-dependent signalling cascade may be the first step in defining the mechanism of action of this enigmatic viral protein.

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Year:  1996        PMID： 8994811     DOI： 10.1016/s0960-9822(02)70770-7

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  5 in total

1.  Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis.

Authors:  B K Benton; A Tinkelenberg; I Gonzalez; F R Cross
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

2.  Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivo.

Authors:  Mamoru Matsubara; Tao Jing; Kumi Kawamura; Naoshi Shimojo; Koiti Titani; Keiichiro Hashimoto; Nobuhiro Hayashi
Journal:  Protein Sci       Date:  2005-01-04       Impact factor: 6.725

3.  The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

Authors:  Z Hanna; X Weng; D G Kay; J Poudrier; C Lowell; P Jolicoeur
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

Review 4.  Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.

Authors:  D I Johnson
Journal:  Microbiol Mol Biol Rev       Date:  1999-03       Impact factor: 11.056

Review 5.  All-Round Manipulation of the Actin Cytoskeleton by HIV.

Authors:  Alberto Ospina Stella; Stuart Turville
Journal:  Viruses       Date:  2018-02-05       Impact factor: 5.048
  5 in total

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