| Literature DB >> 8994224 |
S Jiao1, P J Miller, P A Lapchak.
Abstract
Subsequent to osmotic (mannitol-induced) blood-brain barrier (BBB) opening, [125I]glial cell line-derived neurotrophic factor (GDNF) was detected throughout the ventricular system, associated with the ependymal cell layer and extracellular matrix and to some extent penetrated into the cerebral cortex, subcortical gray matter, substantia nigra, septum, eye and optic nerve at 1 and 24 h following an intracarotid administration. Our study indicates that osmotic opening of the BBB allows for extensive distribution of GDNF throughout the central nervous system (CNS).Entities:
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Year: 1996 PMID： 8994224 DOI： 10.1016/s0304-3940(96)13265-1
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046