Literature DB >> 899145

[A study to the analysis of systolic time intervals (author's transl)].

R Erbel, G G Belz.   

Abstract

For evaluating the degree of accuracy of the STI, a study on 120 healthy young male volunteers was performed. Under standardized conditions ecg, phonocardiogram and carotid arterial pulse were recorded. The following variables were measured: heart cycle interval (RRI), electrical systole (QT), electromechanical systole (QS2), and left ventricular ejection time (LVET). The arithmetic mean was utilized for the consecutive beats 1--5, 1--10, 1--15, and 1--20. The mean of the beats 1--20 was assumed as reference. The increase of the analysed heart cycles from 5 to 20 lead to a decrease of the standard error of RRI, which raised the degree of accuracy. The standard error for RRI decreased from 27.9 to 9.9 ms. Already the analysis of 5 consecutive beats for QT, QS2, and LVET reached the line of identity of the correlation slope compared to 20 analysed heart cycles. The standard error was very small (2.0; 2.9; and 3.0 ms). For clinical-pharmacological studies, the evaluation of 5 consecutive heart cycles for measuring STI leads to a very high degree of accuracy. For an exact measuring of RRI, it is necessary to analyse at least 20 heart cycles.

Entities:  

Mesh:

Year:  1977        PMID: 899145

Source DB:  PubMed          Journal:  Z Kardiol        ISSN: 0300-5860


  12 in total

1.  Haemodynamic effects of roxatidine, an H2-receptor antagonist.

Authors:  A Halabi; A Nokhodian; W Kirch
Journal:  Clin Investig       Date:  1992-02

Review 2.  Systolic time intervals in clinical pharmacology.

Authors:  Q Li; G G Belz
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

3.  Dose-dependent heart rate reducing effect of nizatidine, a histamine H2-receptor antagonist.

Authors:  H Hinrichsen; A Halabi; G Fuhrmann; W Kirch
Journal:  Br J Clin Pharmacol       Date:  1993-05       Impact factor: 4.335

4.  Mechanocardiographic assessment of systolic time intervals in normal children.

Authors:  H E Ulmer; E W Heupel; G Weckesser
Journal:  Basic Res Cardiol       Date:  1982 Mar-Apr       Impact factor: 17.165

5.  Pharmacodynamics of a single dose of quinidine during chronic digoxin treatment. A randomized double blind placebo and sparteine--controlled crossover study.

Authors:  G G Belz; P E Aust; W Doering; M Heinz; B Schneider
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

6.  Influence of nisoldipine on haemodynamic effects and plasma levels of digoxin.

Authors:  W Kirch; J Stenzel; P Dylewicz; H J Hutt; S R Santos; E E Ohnhaus
Journal:  Br J Clin Pharmacol       Date:  1986-08       Impact factor: 4.335

7.  Controlled comparison of the pharmacodynamic effects of nicorandil (SG-75) and isosorbide dinitrate in man.

Authors:  G G Belz; J Matthews; J Heinrich; G Wagner
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

8.  Changes in the effects of nizatidine and famotidine on cardiac performance after pretreatment with ranitidine.

Authors:  A Mescheder; U Ebert; A Halabi; W Kirch
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

9.  Indices of cardiac function during treatment with betamimetic drugs (fenoterol and hexoprenaline).

Authors:  U Siekmann; L Heilmann; M Irmer
Journal:  Arch Gynecol       Date:  1983

10.  Effect of two different doses of nitrendipine on steady-state plasma digoxin level and systolic time intervals.

Authors:  W Kirch; C Logemann; H Heidemann; S R Santos; E E Ohnhaus
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

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