Literature DB >> 8991384

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease.

M Röcken1, M Racke, E M Shevach.   

Abstract

Organ-specific autoimmune diseases are mediated by interferon gamma (IFN-gamma)-producing T helper 1 (Th1) cells. Here, Martin Röcken and colleagues review the experimental basis for an antigen-specific therapeutic approach to inflammatory autoimmune diseases. This strategy involves selective deviation of harmful Th1 responses towards an anti-inflammatory, interleukin 4 (IL-4)-producing Th2 phenotype.

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Year:  1996        PMID： 8991384     DOI： 10.1016/0167-5699(96)80556-1

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  51 in total

1.  Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.

Authors:  T Chitnis; N Najafian; C Benou; A D Salama; M J Grusby; M H Sayegh; S J Khoury
Journal:  J Clin Invest       Date:  2001-09       Impact factor: 14.808

2.  IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB.

Authors:  Y Abu-Amer
Journal:  J Clin Invest       Date:  2001-06       Impact factor: 14.808

3.  Transfer of myelin-specific cells deviated in vitro towards IL-4 production ameliorates ongoing experimental allergic neuritis.

Authors:  C Ekerfelt; C Dahle; R Weissert; M Kvarnström; T Olsson; J Ernerudh
Journal:  Clin Exp Immunol       Date:  2001-01       Impact factor: 4.330

4.  Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis.

Authors:  Yong Woo Lee; Paul H Kim; Won Hee Lee; Anjali A Hirani
Journal:  Biomol Ther (Seoul)       Date:  2010-04       Impact factor: 4.634

5.  CD4+ CD25+ regulatory T cells in human pregnancy: development of a Treg-MLC-ELISPOT suppression assay and indications of paternal specific Tregs.

Authors:  Jenny Mjösberg; Göran Berg; Jan Ernerudh; Christina Ekerfelt
Journal:  Immunology       Date:  2007-01-11       Impact factor: 7.397

6.  Neonatal induction of myelin-specific Th1/Th17 immunity does not result in experimental autoimmune encephalomyelitis and can protect against the disease in adulthood.

Authors:  Harald H Hofstetter; Andra Kovalovsky; Carey L Shive; Paul V Lehmann; Thomas G Forsthuber
Journal:  J Neuroimmunol       Date:  2007-05-04       Impact factor: 3.478

7.  Anti-GAD monoclonal antibody delays the onset of diabetes mellitus in NOD mice.

Authors:  V Menard; H Jacobs; H S Jun; J W Yoon; S W Kim
Journal:  Pharm Res       Date:  1999-07       Impact factor: 4.200

Review 8.  Immunopathology of human inflammatory bowel disease.

Authors:  P Brandtzaeg; G Haraldsen; J Rugtveit
Journal:  Springer Semin Immunopathol       Date:  1997

9.  Role of NADPH oxidase in interleukin-4-induced monocyte chemoattractant protein-1 expression in vascular endothelium.

Authors:  Yong Woo Lee; Won Hee Lee; Paul H Kim
Journal:  Inflamm Res       Date:  2010-03-28       Impact factor: 4.575

10.  In vitro differentiation of peripheral blood T cells towards a type 2 phenotype is impaired in rheumatoid arthritis (RA).

Authors:  S Asselin; H Conjeaud; D Fradelizi; M Breban
Journal:  Clin Exp Immunol       Date:  1998-11       Impact factor: 4.330
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