Literature DB >> 8990958

G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications.

T T Chuang1, L Iacovelli, M Sallese, A De Blasi.   

Abstract

Two patterns of rapid desensitization have been characterized for G protein-coupled receptors: homologous desensitization, which mainly involves G protein-coupled receptor kinases and arrestins, and heterologous desensitization, which mainly involves protein kinases A (PKA) and C (PKC). In this review, Tsu Tshen Chuang and colleagues discuss evidence to show that PKA and PKC can modify the functional state of the G protein-coupled receptor kinases/arrestin homologous desensitization machinery, providing a novel level of cross-talk in signal transduction. Studies on regulation of G protein-coupled receptor kinases and arrestins confirm that the functional state of this machinery may have important consequences for cellular responsiveness and may represent new targets for therapeutic strategies.

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Year:  1996        PMID： 8990958     DOI： 10.1016/s0165-6147(96)10048-1

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  40 in total

Review 1.  Structural features of heterotrimeric G-protein-coupled receptors and their modulatory proteins.

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Authors:  M G Waugh; R A Challiss; G Berstein; S R Nahorski; A B Tobin
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5.  Peptidergic activation of transcription and secretion in chromaffin cells. Cis and trans signaling determinants of pituitary adenylyl cyclase-activating polypeptide (PACAP).

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6.  GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.

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7.  Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

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8.  A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes.

Authors:  Valérie Capra; Maria Rosa Accomazzo; Fabrizio Gardoni; Silvia Barbieri; G Enrico Rovati
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9.  EP1- and FP-mediated cross-desensitization of the alpha (alpha) and beta (beta) isoforms of the human thromboxane A2 receptor.

Authors:  Leanne P Kelley-Hickie; B Therese Kinsella
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10.  Norepinephrine-mediated regulation of 5HT1 receptor functioning in human platelets.

Authors:  M L Trincavelli; S Cuboni; M Montali; S Santaguida; A Lucacchini; C Martini
Journal:  Neurochem Res       Date:  2008-02-13       Impact factor: 3.996
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