Literature DB >> 8989571

Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration.

R Milner1, H J Anderson, R F Rippon, J S McKay, R J Franklin, M A Marchionni, R Reynolds, C Ffrench-Constant.   

Abstract

We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development.

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Year:  1997        PMID： 8989571     DOI： 10.1002/(sici)1098-1136(199701)19:1<85::aid-glia9>3.0.co;2-9

Source DB:  PubMed          Journal:  Glia        ISSN： 0894-1491            Impact factor:   7.452


  29 in total

1.  Cell-surface glycoprotein of oligodendrocyte progenitors involved in migration.

Authors:  A Niehaus; J Stegmüller; M Diers-Fenger; J Trotter
Journal:  J Neurosci       Date:  1999-06-15       Impact factor: 6.167

2.  Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells.

Authors:  Pablo M Paez; Daniel J Fulton; Vilma Spreur; Vance Handley; Anthony T Campagnoni
Journal:  J Neurosci       Date:  2010-05-05       Impact factor: 6.167

3.  Differential Regulation of MeCP2 Phosphorylation by Laminin in Oligodendrocytes.

Authors:  Zalak S Parikh; Ashutosh Tripathi; Prakash P Pillai
Journal:  J Mol Neurosci       Date:  2017-06-14       Impact factor: 3.444

Review 4.  Cell therapy for multiple sclerosis.

Authors:  Tamir Ben-Hur
Journal:  Neurotherapeutics       Date:  2011-10       Impact factor: 7.620

5.  Schwann cells induce Proliferation and Migration of Oligodendrocyte Precursor Cells Through Secretion of PDGF-AA and FGF-2.

Authors:  Yue-Juan Chen; Jing-Xing Zhang; Lin Shen; Qi Qi; Xiao-Xin Cheng; Zheng-Rong Zhong; Zhi-Quan Jiang; Rui Wang; He-Zuo Lü; Jian-Guo Hu
Journal:  J Mol Neurosci       Date:  2015-06-05       Impact factor: 3.444

6.  Transplanted oligodendrocyte progenitor cells expressing a dominant-negative FGF receptor transgene fail to migrate in vivo.

Authors:  D J Osterhout; S Ebner; J Xu; D M Ornitz; G A Zazanis; R D McKinnon
Journal:  J Neurosci       Date:  1997-12-01       Impact factor: 6.167

7.  The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis.

Authors:  B Cannella; C J Hoban; Y L Gao; R Garcia-Arenas; D Lawson; M Marchionni; D Gwynne; C S Raine
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

Review 8.  The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis.

Authors:  Alexander Annenkov
Journal:  Mol Neurobiol       Date:  2009-08-29       Impact factor: 5.590

9.  Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx.

Authors:  Pablo M Paez; Daniel J Fulton; Vilma Spreuer; Vance Handley; Celia W Campagnoni; Wendy B Macklin; Christopher Colwell; Anthony T Campagnoni
Journal:  J Neurosci       Date:  2009-05-20       Impact factor: 6.167

10.  pERK1/2 Peripheral Recruitment and Filopodia Protrusion Augment Oligodendrocyte Progenitor Cell Migration: Combined Effects of PDGF-A and Fibronectin.

Authors:  Ashutosh Tripathi; Zalak S Parikh; Parvez Vora; Emma E Frost; Prakash P Pillai
Journal:  Cell Mol Neurobiol       Date:  2016-03-18       Impact factor: 5.046
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