Iron and thermoregulation: a review.

Poor temperature regulation in both human and animal models has been associated with iron deficiency anemia. The review examines the evidence for causality in both animals and humans, as well as provides an overview of temperature regulation in homeotherms. A number of investigations conclude that anemia is a central component of the inability of iron-deficient individuals to temperature regulate when they are cold stressed. This is apparently due to effects both on heat production and heat loss rates. The former is related to poor thyroid function in iron deficiency and the latter to the competing demands for tissue oxygenation vs. decreased flood flow to minimize heat losses to the environment. Future research needs are outlined that require integration of endocrinology, physiology, and nutrition disciplines.