OBJECTIVE: The purpose of this study was to evaluate whether the concentration of beta-nucleoside triphosphate is lower in the basal ganglia of depressed subjects. METHOD: In vivo 31P magnetic resonance spectra were acquired from a 45-cm3 region surrounding the basal ganglia of 35 unmedicated depressed subjects and 18 comparison subjects. RESULTS: beta-Nucleoside triphosphate, which arises primarily from beta-ATP, was 16% lower in the depressed subjects than in the comparison subjects. CONCLUSIONS: The low level of beta-nucleoside triphosphate is consistent with an abnormality of high-energy phosphate metabolism in the basal ganglia of subjects with major depression.
OBJECTIVE: The purpose of this study was to evaluate whether the concentration of beta-nucleoside triphosphate is lower in the basal ganglia of depressed subjects. METHOD: In vivo 31P magnetic resonance spectra were acquired from a 45-cm3 region surrounding the basal ganglia of 35 unmedicated depressed subjects and 18 comparison subjects. RESULTS:beta-Nucleoside triphosphate, which arises primarily from beta-ATP, was 16% lower in the depressed subjects than in the comparison subjects. CONCLUSIONS: The low level of beta-nucleoside triphosphate is consistent with an abnormality of high-energy phosphate metabolism in the basal ganglia of subjects with major depression.
Authors: Douglas G Kondo; Young-Hoon Sung; Tracy L Hellem; Kristen K Fiedler; Xianfeng Shi; Eun-Kee Jeong; Perry F Renshaw Journal: J Affect Disord Date: 2011-08-09 Impact factor: 4.839
Authors: David G Harper; J Eric Jensen; Caitlin Ravichandran; Roy H Perlis; Maurizio Fava; Perry F Renshaw; Dan V Iosifescu Journal: Neuropsychopharmacology Date: 2016-09-02 Impact factor: 7.853
Authors: Paolo Cassano; Samuel R Petrie; Michael R Hamblin; Theodore A Henderson; Dan V Iosifescu Journal: Neurophotonics Date: 2016-03-04 Impact factor: 3.593