BACKGROUND: Argyrophilic nucleolar organizer regions (AgNORs) represent a tissue marker of cell proliferative activity. The purpose of this study was to assess the prognostic value of AgNORs expression in oral squamous cell carcinoma (SCC). METHODS: The AgNORs area/nucleus was studied in paraffin sections by means of digital image analysis in 43 cases of stage II oral tongue and floor of the mouth SCC. RESULTS: Time free of disease was considered a dependent variable of a binary indicator of AgNORs expression (7.77 microns2/nucleus as a cut-off point). High AgNORs level was associated with a statistically significant negative effect on recurrence-free interval of disease in a Cox proportional hazards models controlled for occult lymph node metastasis, involvement of the surgical margins, thickness of the lesion, and vascular invasion. CONCLUSIONS: The AgNORs area increased the capability of predicting which patients have a high risk of recurrence of cancer, and its evaluation may provide useful information for the therapeutic approach to the oral tongue and floor of the mouth SCC.
BACKGROUND: Argyrophilic nucleolar organizer regions (AgNORs) represent a tissue marker of cell proliferative activity. The purpose of this study was to assess the prognostic value of AgNORs expression in oral squamous cell carcinoma (SCC). METHODS: The AgNORs area/nucleus was studied in paraffin sections by means of digital image analysis in 43 cases of stage II oral tongue and floor of the mouth SCC. RESULTS: Time free of disease was considered a dependent variable of a binary indicator of AgNORs expression (7.77 microns2/nucleus as a cut-off point). High AgNORs level was associated with a statistically significant negative effect on recurrence-free interval of disease in a Cox proportional hazards models controlled for occult lymph node metastasis, involvement of the surgical margins, thickness of the lesion, and vascular invasion. CONCLUSIONS: The AgNORs area increased the capability of predicting which patients have a high risk of recurrence of cancer, and its evaluation may provide useful information for the therapeutic approach to the oral tongue and floor of the mouth SCC.
Authors: João Adolfo Costa Hanemann; Marta Miyazawa; Mireile São Geraldo dos Santos Souza Journal: J Appl Oral Sci Date: 2011 May-Jun Impact factor: 2.698
Authors: Horst Kokemueller; Majeed Rana; Jennifer Rublack; Andre Eckardt; Frank Tavassol; Paul Schumann; Daniel Lindhorst; Martin Ruecker; Nils-Claudius Gellrich Journal: Head Neck Oncol Date: 2011-05-21
Authors: J T Korpi; V Kervinen; H Mäklin; A Väänänen; M Lahtinen; E Läärä; A Ristimäki; G Thomas; M Ylipalosaari; P Aström; C Lopez-Otin; T Sorsa; S Kantola; E Pirilä; T Salo Journal: Br J Cancer Date: 2008-02-05 Impact factor: 7.640