Literature DB >> 8988595

Bastadin 20 and bastadin O-sulfate esters from Ianthella basta: novel modulators of the Ry1R FKBP12 receptor complex.

M A Franklin1, S G Penn, C B Lebrilla, T H Lam, I N Pessah, T F Molinski.   

Abstract

New compounds bastadin 20 (9), 15,34-O-disulfatobastadin 7 (10), and 10-O-sulfatobastadin 3 (11) were isolated from Ianthella basta collected in Exmouth Gulf, Western Australia. Compounds 10 and 11 exhibited moderate differential activity as SR Ca2+ channel agonists (EC50 13.6 and 100 microM, respectively) of the Ry1R FKBP12 complex, while the potency of 9 was almost half that of 10 (EC50 20.6 microM). The problem of dereplication of bastadins was addressed using 1H-NMR "fingerprinting" of MeO signals in the corresponding permethyl bastadin derivatives.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8988595     DOI： 10.1021/np960507g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

Review 1.  Exploitation of marine algae: biogenic compounds for potential antifouling applications.

Authors:  Punyasloke Bhadury; Phillip C Wright
Journal:  Planta       Date:  2004-06-24       Impact factor: 4.116

Review 2.  The marine bromotyrosine derivatives.

Authors:  Jiangnan Peng; Jing Li; Mark T Hamann
Journal:  Alkaloids Chem Biol       Date:  2005

3.  Chitin-based scaffolds are an integral part of the skeleton of the marine demosponge Ianthella basta.

Authors:  E Brunner; H Ehrlich; P Schupp; R Hedrich; S Hunoldt; M Kammer; S Machill; S Paasch; V V Bazhenov; D V Kurek; T Arnold; S Brockmann; M Ruhnow; R Born
Journal:  J Struct Biol       Date:  2009-06-28       Impact factor: 2.867

4.  Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum.

Authors:  Albert W W Van Wyk; Karina M Zuck; Tawnya C McKee
Journal:  J Nat Prod       Date:  2011-04-13       Impact factor: 4.050

5.  Isolation of bastadin-6-O-sulfate and expedient purifications of bastadins-4, -5 and -6 from extracts of Ianthella basta.

Authors:  Christopher J Gartshore; Mariam N Salib; August A Renshaw; Tadeusz F Molinski
Journal:  Fitoterapia       Date:  2017-12-05       Impact factor: 2.882

6.  Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex.

Authors:  Makoto N Masuno; Isaac N Pessah; Marilyn M Olmstead; Tadeusz F Molinski
Journal:  J Med Chem       Date:  2006-07-27       Impact factor: 7.446

7.  Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Authors:  Jing Zheng; Shaun M K McKinnie; Abrahim El Gamal; Wei Feng; Yao Dong; Vinayak Agarwal; William Fenical; Abdhesh Kumar; Zhengyu Cao; Bradley S Moore; Isaac N Pessah
Journal:  Environ Sci Technol       Date:  2018-04-20       Impact factor: 9.028

8.  The natural production of organobromine compounds.

Authors:  G W Gribble
Journal:  Environ Sci Pollut Res Int       Date:  2000-03       Impact factor: 4.223

9.  Additional insights on the bastadins: isolation of analogues from the sponge Ianthella cf. reticulata and exploration of the oxime configurations.

Authors:  Laurent Calcul; Wayne D Inman; Alexi A Morris; Karen Tenney; Joseline Ratnam; James H McKerrow; Frederick A Valeriote; Phillip Crews
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

10.  Naturally Drug-Loaded Chitin: Isolation and Applications.

Authors:  Valentine Kovalchuk; Alona Voronkina; Björn Binnewerg; Mario Schubert; Liubov Muzychka; Marcin Wysokowski; Mikhail V Tsurkan; Nicole Bechmann; Iaroslav Petrenko; Andriy Fursov; Rajko Martinovic; Viatcheslav N Ivanenko; Jane Fromont; Oleg B Smolii; Yvonne Joseph; Marco Giovine; Dirk Erpenbeck; Michael Gelinsky; Armin Springer; Kaomei Guan; Stefan R Bornstein; Hermann Ehrlich
Journal:  Mar Drugs       Date:  2019-10-10       Impact factor: 5.118
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.