| Literature DB >> 8988338 |
M Zenmyo1, K Hiraoka, T Sasaguri, S Komiya, A Inoue, M Morimatsu, Y Sasaguri.
Abstract
In the present study, we investigated the effect of interleukin-4 (IL-4) on metalloproteinase 1 (MMP-1/tissue collagenase) production in human rheumatoid synovial fibroblasts. Northern blot analysis revealed that addition of IL-4 with or without histamine stimulated the cells to increase the amount of proMMP-1 mRNA, and the IL-4 with histamine addition resulted in a 3.3-fold increase compared with histamine only. Furthermore, IL-4 itself stimulated the expression of histamine H1 receptor mRNA. These results suggest that IL-4 may play an important role in joint destruction in RA.Entities:
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Year: 1996 PMID： 8988338 DOI： 10.1080/15216549600201903
Source DB: PubMed Journal: Biochem Mol Biol Int ISSN： 1039-9712