| Literature DB >> 8988238 |
H Michelakakis1, C Spanou, A Kondyli, E Dimitriou, S Van Weely, C E Hollak, M H Van Oers, J M Aerts.
Abstract
Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease.Entities:
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Year: 1996 PMID： 8988238 DOI： 10.1016/s0925-4439(96)00056-7
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002