Literature DB >> 8987494

Genes, enzymes and secondary metabolites in industrial microorganisms. The 1995 Thom Award Lecture.

T Beppu1.   

Abstract

Apparently contrasting approaches, ie genetic engineering and screening of new microorganisms, play essential complementary roles to develop current industrial microbiology. Three topics, production and modification of milk-clotting proteinases by genetic engineering, hormonal control of secondary metabolism in streptomycetes, and screening of bioactive metabolites, are introduced as cases of such a hybrid approach, while symbiotic microorganisms are discussed as an example of the vast terra incognita still remaining for the future microbiology.

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Year:  1996        PMID： 8987494     DOI： 10.1007/bf01570116

Source DB:  PubMed          Journal:  J Ind Microbiol        ISSN： 0169-4146


  14 in total

Review 1.  Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators.

Authors:  W C Fuqua; S C Winans; E P Greenberg
Journal:  J Bacteriol       Date:  1994-01       Impact factor: 3.490

2.  Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Authors:  M Yoshida; M Kijima; M Akita; T Beppu
Journal:  J Biol Chem       Date:  1990-10-05       Impact factor: 5.157

3.  Secretion by yeast of the zymogen form of Mucor rennin, an aspartic proteinase of Mucor pusillus, and its conversion to the mature form.

Authors:  R Hiramatsu; J Aikawa; S Horinouchi; T Beppu
Journal:  J Biol Chem       Date:  1989-10-05       Impact factor: 5.157

Review 4.  Signal transduction and secondary metabolism: prospects for controlling productivity.

Authors:  T Beppu
Journal:  Trends Biotechnol       Date:  1995-07       Impact factor: 19.536

5.  Cloning and characterization of the A-factor receptor gene from Streptomyces griseus.

Authors:  H Onaka; N Ando; T Nihira; Y Yamada; T Beppu; S Horinouchi
Journal:  J Bacteriol       Date:  1995-11       Impact factor: 3.490

6.  Cloning, nucleotide sequences, and overexpression in Escherichia coli of tandem copies of a tryptophanase gene in an obligately symbiotic thermophile, Symbiobacterium thermophilum.

Authors:  T Hirahara; S Suzuki; S Horinouchi; T Beppu
Journal:  Appl Environ Microbiol       Date:  1992-08       Impact factor: 4.792

7.  A gene cluster involved in aerial mycelium formation in Streptomyces griseus encodes proteins similar to the response regulators of two-component regulatory systems and membrane translocators.

Authors:  K Ueda; K Miyake; S Horinouchi; T Beppu
Journal:  J Bacteriol       Date:  1993-04       Impact factor: 3.490

8.  Cloning, nucleotide sequence, and overexpression in Escherichia coli of the beta-tyrosinase gene from an obligately symbiotic thermophile, Symbiobacterium thermophilum.

Authors:  T Hirahara; S Horinouchi; T Beppu
Journal:  Appl Microbiol Biotechnol       Date:  1993-06       Impact factor: 4.813

9.  Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase.

Authors:  A Matsumoto; S K Hong; H Ishizuka; S Horinouchi; T Beppu
Journal:  Gene       Date:  1994-08-19       Impact factor: 3.688

10.  Virginiae butanolide binding protein from Streptomyces virginiae. Evidence that VbrA is not the virginiae butanolide binding protein and reidentification of the true binding protein.

Authors:  S Okamoto; K Nakamura; T Nihira; Y Yamada
Journal:  J Biol Chem       Date:  1995-05-19       Impact factor: 5.157
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