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Literature DB >> 8987400

Evidence for a Ras/Ral signaling cascade.

Abstract

It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.

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Year: 1996 PMID： 8987400 DOI： 10.1016/s0968-0004(96)10058-x

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

46 in total

1. The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.

Authors: X K Tong; N K Hussain; E de Heuvel; A Kurakin; E Abi-Jaoude; C C Quinn; M F Olson; R Marais; D Baranes; B K Kay; P S McPherson
Journal: EMBO J Date: 2000-03-15 Impact factor: 11.598

2. Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth.

Authors: T Goi; G Rusanescu; T Urano; L A Feig
Journal: Mol Cell Biol Date: 1999-03 Impact factor: 4.272

3. Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.

Authors: D O Henry; S A Moskalenko; K J Kaur; M Fu; R G Pestell; J H Camonis; M A White
Journal: Mol Cell Biol Date: 2000-11 Impact factor: 4.272

4. Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.

Authors: N D De Ruiter; B M Burgering; J L Bos
Journal: Mol Cell Biol Date: 2001-12 Impact factor: 4.272

5. Functional analysis of CNK in RAS signaling.

Authors: M Therrien; A M Wong; E Kwan; G M Rubin
Journal: Proc Natl Acad Sci U S A Date: 1999-11-09 Impact factor: 11.205

6. RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells.

Authors: Akiyuki Takaya; Yusuke Ohba; Kazuo Kurokawa; Michiyuki Matsuda
Journal: Mol Biol Cell Date: 2004-03-19 Impact factor: 4.138

Evidence for a Ras/Ral signaling cascade.

1. The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.

2. Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth.

3. Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.

4. Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.

5. Functional analysis of CNK in RAS signaling.

6. RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells.

7. The small GTPase RalA targets filamin to induce filopodia.

Review 8. C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins.

9. Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation.

10. A novel Ras inhibitor, Eri1, engages yeast Ras at the endoplasmic reticulum.