Literature DB >> 8987071

Drug delivery issues in vaccine development.

M F Powell1.   

Abstract

Although significant headway has been made in vaccine development, there are several delivery-related issues that must be overcome to advance tomorrow's candidate vaccines. Some of these are in the areas of: single-shot subunit vaccines, therapeutic vaccines for cancer, the use of cytokines as vaccine adjuvants, DNA-based vaccines, and the development of vaccines that provide sterilizing immunity, as might be required for an affective HIV-1 prophylactic vaccine. The hurdles for vaccine advancement in these areas are briefly described.

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Year:  1996        PMID： 8987071     DOI： 10.1023/a:1016064504346

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  109 in total

1.  Treatment of metastatic melanoma with an autologous tumor-cell vaccine: clinical and immunologic results in 64 patients.

Authors:  D Berd; H C Maguire; P McCue; M J Mastrangelo
Journal:  J Clin Oncol       Date:  1990-11       Impact factor: 44.544

2.  How many injections of poliomyelitis vaccine for effective and durable immunity.

Authors:  J E SALK
Journal:  J Am Med Assoc       Date:  1958-05-03

3.  Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

Authors:  M S Anderson; J Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

4.  Reduction of disulfide bonds within lysosomes is a key step in antigen processing.

Authors:  D S Collins; E R Unanue; C V Harding
Journal:  J Immunol       Date:  1991-12-15       Impact factor: 5.422

Review 5.  Gene introduction into animal tissues.

Authors:  M Nakanishi
Journal:  Crit Rev Ther Drug Carrier Syst       Date:  1995       Impact factor: 4.889

Review 6.  Vaccinology of poliomyelitis.

Authors:  D Salk; J Salk
Journal:  Vaccine       Date:  1984-03       Impact factor: 3.641

7.  Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus.

Authors:  B S Graham; G S Henderson; Y W Tang; X Lu; K M Neuzil; D G Colley
Journal:  J Immunol       Date:  1993-08-15       Impact factor: 5.422

8.  Deficient T-cell responses in non-responders to hepatitis B vaccination: absence of TH1 cytokine production.

Authors:  J Vingerhoets; G Vanham; L Kestens; G Penne; G Leroux-Roels; P Gigase
Journal:  Immunol Lett       Date:  1994-02       Impact factor: 3.685

9.  Vaccine-associated poliomyelitis in the United States, 1961-1972.

Authors:  L B Schonberger; J E McGowan; M B Gregg
Journal:  Am J Epidemiol       Date:  1976-08       Impact factor: 4.897

10.  Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins.

Authors:  D D Ho; M G Sarngadharan; M S Hirsch; R T Schooley; T R Rota; R C Kennedy; T C Chanh; V L Sato
Journal:  J Virol       Date:  1987-06       Impact factor: 5.103
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  3 in total

Review 1.  Cytokine regulation of epithelial permeability and ion transport.

Authors:  D M McKay; A W Baird
Journal:  Gut       Date:  1999-02       Impact factor: 23.059

Review 2.  Flow cytometry applications in pharmacodynamics and drug delivery.

Authors:  M Ramanathan
Journal:  Pharm Res       Date:  1997-09       Impact factor: 4.200

Review 3.  Innovative strategies for co-delivering antigens and CpG oligonucleotides.

Authors:  Yogita Krishnamachari; Aliasger K Salem
Journal:  Adv Drug Deliv Rev       Date:  2009-01-19       Impact factor: 15.470
  3 in total

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