OBJECTIVE: Baroreflex sensitivity (BRS) increases during sleep, whereas arterial blood pressure falls. Some hypertensive patients do not have a nocturnal fall in blood pressure (non-dippers). The objective was to ascertain whether there is a difference between 24 h BRS values in dippers and non-dippers that might account for the difference in nocturnal blood pressure behaviour. DESIGN: In a group of consecutive untreated hypertensive patients undergoing 24 h ambulatory intra-arterial blood pressure (IABP) monitoring, 18 were non-dippers i.e., their mean IABP during sleep failed to drop by 10% of their waking IABP. Each non-dipper was matched for age and waking IABP with two dippers. The BRS had previously been assessed with the "Oxford' bolus phenylephrine technique; spontaneous BRS was assessed throughout the 24 h period by off-line computer analysis of spontaneous variations in IABP and R-R interval. RESULTS: In both groups there was a significant increase in spontaneous BRS during sleep (P < 0.0001 for dippers, P < 0.0001 for non-dippers). There was no significant difference between spontaneous BRS in dippers and non-dippers, when they were either awake or asleep. CONCLUSION: BRS did not differ significantly between dippers and non-dippers, when they were either awake or asleep. Changes in BRS during sleep are not likely to account for the abnormal dipping pattern in a minority of hypertensives and are not likely to contribute to the normally observed nocturnal fall in blood pressure.
OBJECTIVE: Baroreflex sensitivity (BRS) increases during sleep, whereas arterial blood pressure falls. Some hypertensivepatients do not have a nocturnal fall in blood pressure (non-dippers). The objective was to ascertain whether there is a difference between 24 h BRS values in dippers and non-dippers that might account for the difference in nocturnal blood pressure behaviour. DESIGN: In a group of consecutive untreated hypertensivepatients undergoing 24 h ambulatory intra-arterial blood pressure (IABP) monitoring, 18 were non-dippers i.e., their mean IABP during sleep failed to drop by 10% of their waking IABP. Each non-dipper was matched for age and waking IABP with two dippers. The BRS had previously been assessed with the "Oxford' bolus phenylephrine technique; spontaneous BRS was assessed throughout the 24 h period by off-line computer analysis of spontaneous variations in IABP and R-R interval. RESULTS: In both groups there was a significant increase in spontaneous BRS during sleep (P < 0.0001 for dippers, P < 0.0001 for non-dippers). There was no significant difference between spontaneous BRS in dippers and non-dippers, when they were either awake or asleep. CONCLUSION: BRS did not differ significantly between dippers and non-dippers, when they were either awake or asleep. Changes in BRS during sleep are not likely to account for the abnormal dipping pattern in a minority of hypertensives and are not likely to contribute to the normally observed nocturnal fall in blood pressure.
Authors: Juan J Figueroa; Darlene M Bott-Kitslaar; Joaquin A Mercado; Jeffrey R Basford; Paola Sandroni; Win-Kuang Shen; David M Sletten; Tonette L Gehrking; Jade A Gehrking; Phillip A Low; Wolfgang Singer Journal: Auton Neurosci Date: 2014-06-21 Impact factor: 3.145
Authors: Prossie Merab Ingabire; Dike B Ojji; Brian Rayner; Elijah Ogola; Albertino Damasceno; Erika Jones; Anastase Dzudie; Okechukwu S Ogah; Neil Poulter; Mahmoud U Sani; Felix Ayub Barasa; Grace Shedul; John Mukisa; David Mukunya; Bonnie Wandera; Charles Batte; James Kayima; Shahiemah Pandie; Charles Kiiza Mondo Journal: BMC Cardiovasc Disord Date: 2021-05-22 Impact factor: 2.298