Literature DB >> 8986825

A novel host factor for integration of mycobacteriophage L5.

M L Pedulla1, M H Lee, D C Lever, G F Hatfull.   

Abstract

Bacterial integration host factors (IHFs) play central roles in the cellular processes of recombination, DNA replication, transcription, and bacterial pathogenesis. We describe here a novel mycobacterial IHF (mIHF) of Mycobacterium smegmatis and Mycobacterium tuberculosis that stimulates integration of mycobacteriophage L5. mIHF is the product of a single gene and is unrelated at the sequence level to other integration host factors. By itself, mIHF does not bind preferentially to attP DNA, although it significantly alters the pattern of integrase (Int) binding, promoting the formation of specific integrase-mIHF-attP intasome complexes.

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Year:  1996        PMID： 8986825      PMCID： PMC26418          DOI： 10.1073/pnas.93.26.15411

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

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Journal:  Biochimie       Date:  1994       Impact factor: 4.079

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Journal:  Cell       Date:  1984-12       Impact factor: 41.582

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Journal:  Cold Spring Harb Symp Quant Biol       Date:  1981

8.  Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guérin.

Authors:  M H Lee; L Pascopella; W R Jacobs; G F Hatfull
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

9.  Characterization of the binding sites of two proteins involved in the bacteriophage P2 site-specific recombination system.

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Journal:  J Bacteriol       Date:  1993-03       Impact factor: 3.490

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Journal:  J Mol Biol       Date:  1986-09-20       Impact factor: 5.469
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  19 in total

1.  Assembly and activation of site-specific recombination complexes.

Authors:  C E Peña; J M Kahlenberg; G F Hatfull
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

2.  Method to integrate multiple plasmids into the mycobacterial chromosome.

Authors:  Beatrice Saviola; William R Bishai
Journal:  Nucleic Acids Res       Date:  2004-01-12       Impact factor: 16.971

3.  Phage L5 integrating vectors are present within the Mycobacterial Cell in an equilibrium between integrated and excised states.

Authors:  Beatrice Saviola
Journal:  Cancer Ther       Date:  2009-01

4.  Characterization of the mIHF gene of Mycobacterium smegmatis.

Authors:  M L Pedulla; G F Hatfull
Journal:  J Bacteriol       Date:  1998-10       Impact factor: 3.490

5.  The host factor polyhedrin promoter binding protein (PPBP) is involved in transcription from the baculovirus polyhedrin gene promoter.

Authors:  S Ghosh; A Jain; B Mukherjee; S Habib; S E Hasnain
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

6.  Protein-DNA complexes in mycobacteriophage L5 integrative recombination.

Authors:  C E Peña; J M Kahlenberg; G F Hatfull
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490

7.  The role of supercoiling in mycobacteriophage L5 integrative recombination.

Authors:  C E Peña; J M Kahlenberg; G F Hatfull
Journal:  Nucleic Acids Res       Date:  1998-09-01       Impact factor: 16.971

8.  The structure of Xis reveals the basis for filament formation and insight into DNA bending within a mycobacteriophage intasome.

Authors:  Shweta Singh; Joseph G Plaks; Nicholas J Homa; Christopher G Amrich; Annie Héroux; Graham F Hatfull; Andrew P VanDemark
Journal:  J Mol Biol       Date:  2013-10-07       Impact factor: 5.469

9.  Two widely spaced initiator binding sites create an HMG1-dependent parvovirus rolling-hairpin replication origin.

Authors:  S F Cotmore; J Christensen; P Tattersall
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

10.  Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination.

Authors:  Narayanaswamy Sharadamma; Yadumurthy Harshavardhana; K Muniyappa
Journal:  J Bacteriol       Date:  2017-09-05       Impact factor: 3.490
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