Probable nefazodone-induced mania in a patient with unreported bipolar disorder.

Nefazodone is a new antidepressant exhibiting properties of selective serotonin reuptake inhibition and serotonin-2 receptor antagonism. There has been only one other published case of induction of mania in a patient treated with nefazodone. This report describes a second case of probable induction of mania with nefazodone therapy and briefly reviews clinical and theoretical considerations involved in this process.