Literature DB >> 8985709

Cholecystokinin in anxiety.

H J van Megen1, H G Westenberg, J A den Boer, R S Kahn.   

Abstract

Cholecystokinin (CCK) plays an important role in both the alimentary tract and the central nervous system (CNS). At present it seems to be the most abundant neuropeptide in the CNS. This paper reviews the CCK neuronal system and its interactions with gamma-aminobutyric acid (GABA) and serotonin (5-hydroxytryptamine; 5-HT). In addition, its putative role in anxiety will be discussed on the basis of animal data and studies in healthy volunteers and panic disorder patients. According to these investigations, the CCK4 challenge test fulfills most criteria for an ideal panicogenic agent and evidence has been found that CCKB receptor antagonists might possess anxiolytic properties in man.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8985709     DOI： 10.1016/s0924-977x(96)00038-7

Source DB:  PubMed          Journal:  Eur Neuropsychopharmacol        ISSN： 0924-977X            Impact factor:   4.600


  20 in total

1.  cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of BALB/c mice subjected to chronic mild stress.

Authors:  Yanyong Liu; Nan Yang; Pingping Zuo
Journal:  Cell Mol Neurobiol       Date:  2010-06-09       Impact factor: 5.046

2.  New CCK2 agonists confirming the heterogeneity of CCK2 receptors: characterisation of BBL454.

Authors:  Bruno Bellier; Dominique Crété; Marie-Emmanuelle Million; Françoise Beslot; André Bado; Christiane Garbay; Valérie Daugé
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-10-08       Impact factor: 3.000

3.  Wiring and volume transmission in rat amygdala. Implications for fear and anxiety.

Authors:  Miguel Pérez de la Mora; Kirsten X Jacobsen; Minerva Crespo-Ramírez; Candy Flores-Gracia; Kjell Fuxe
Journal:  Neurochem Res       Date:  2008-05-13       Impact factor: 3.996

4.  Interaction between cholecystokinin and the fibroblast growth factor system in the ventral tegmental area of selectively bred high- and low-responder rats.

Authors:  S J Ballaz; J Perez; M Waselus; H Akil; S J Watson
Journal:  Neuroscience       Date:  2013-10-09       Impact factor: 3.590

5.  Enhanced cortical extracellular levels of cholecystokinin-like material in a model of anticipation of social defeat in the rat.

Authors:  C Becker; M H Thièbot; Y Touitou; M Hamon; F Cesselin; J J Benoliel
Journal:  J Neurosci       Date:  2001-01-01       Impact factor: 6.167

6.  cDNA microarray analysis of gene expression in anxious PVG and SD rats after cat-freezing test.

Authors:  H Wang; Y Z Zhu; P T-H Wong; J M Farook; A L Teo; L K H Lee; S Moochhala
Journal:  Exp Brain Res       Date:  2003-02-19       Impact factor: 1.972

7.  Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in male rats: behavioral and biochemical studies.

Authors:  Judith Andre; Brigitte Zeau; Michel Pohl; François Cesselin; Jean-Jacques Benoliel; Chrystel Becker
Journal:  J Neurosci       Date:  2005-08-31       Impact factor: 6.167

8.  Response to pentagastrin after acute phenylalanine and tyrosine depletion in healthy men: a pilot study.

Authors:  N Coupland; L Zedkova; G Sanghera; M Leyton; J M Le Mellédo
Journal:  J Psychiatry Neurosci       Date:  2001-05       Impact factor: 6.186

9.  Elevated cholecystokininergic tone constitutes an important molecular/neuronal mechanism for the expression of anxiety in the mouse.

Authors:  Qian Chen; Akira Nakajima; Corbin Meacham; Ya-Ping Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-28       Impact factor: 11.205

10.  Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers.

Authors:  Daniela Eser; Gregor Leicht; Jürgen Lutz; Stephan Wenninger; Valerie Kirsch; Cornelius Schüle; Susanne Karch; Thomas Baghai; Oliver Pogarell; Christine Born; Rainer Rupprecht; Christoph Mulert
Journal:  Hum Brain Mapp       Date:  2009-02       Impact factor: 5.038
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.