| Literature DB >> 8985214 |
M J Mayaux1, E Dussaix, J Isopet, C Rekacewicz, L Mandelbrot, N Ciraru-Vigneron, M C Allemon, V Chambrin, C Katlama, J F Delfraissy, J Puel.
Abstract
Virus load in pregnancy and its relation to mother-to-child human immunodeficiency virus (HIV) transmission were studied prospectively. From 1989 to 1994, 320 HIV-infected women from 18 centers had plasma samples stored. Among women not receiving antiretroviral therapy, the polymerase chain reaction RNA level was 3.6 log at delivery, and 15% of women had levels below the detection limit. There was no variation during pregnancy. Women born in sub-Saharan Africa had lower RNA levels, although their CD4 cell distribution did not differ from that in other women. Among 236 evaluable children, 19% +/- 5% were infected. Transmission occurred in 12% of cases (confidence interval, 5%-22%) with <1000 copies/mL versus 29% +/- 10% of those with >10,000 copies/mL (P < .02). Maternal virus load appears strongly related to HIV transmission to the child.Entities:
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Year: 1997 PMID： 8985214 DOI： 10.1093/infdis/175.1.172
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226