Literature DB >> 8984742

Prozac: panacea or puzzle?

S C Stanford1.   

Abstract

Selective 5-HT (serotonin) reuptake inhibitors (SSRIs) lack many of the adverse side-effects of older antidepressants. One of these compounds, fluoxetine (Prozac), has acquired manifest public awareness that is not evident with other SSRIs. Here, Clare Stanford compares the basic pharmacology of SSRIs to determine whether fluoxetine has any atypical features, and thus provide scientific justification for the attention focused on this compound. Ironically, fluoxetine might be distinctive in that it is the least selective SSRI and has marked effects on catecholamine function in the brain.

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Year:  1996        PMID： 8984742     DOI： 10.1016/0165-6147(96)81591-4

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  8 in total

1.  The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain.

Authors:  V Sanchez; J Camarero; B Esteban; M J Peter; A R Green; M I Colado
Journal:  Br J Pharmacol       Date:  2001-09       Impact factor: 8.739

2.  Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine.

Authors:  B R Tuladhar; B Costall; R J Naylor
Journal:  Br J Pharmacol       Date:  2002-05       Impact factor: 8.739

3.  Rotating disk electrode voltammetric measurements of serotonin transporter kinetics in synaptosomes.

Authors:  Catherine E Hagan; John F Neumaier; James O Schenk
Journal:  J Neurosci Methods       Date:  2010-08-14       Impact factor: 2.390

4.  Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors.

Authors:  John F Cryan; Olivia F O'Leary; Sung-Ha Jin; Julie C Friedland; Ming Ouyang; Bradford R Hirsch; Michelle E Page; Ashutosh Dalvi; Steven A Thomas; Irwin Lucki
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

5.  Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice.

Authors:  D J P David; M Bourin; G Jego; C Przybylski; P Jolliet; A M Gardier
Journal:  Br J Pharmacol       Date:  2003-10-06       Impact factor: 8.739

Review 6.  Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy.

Authors:  Lynette C Daws
Journal:  Pharmacol Ther       Date:  2008-10-29       Impact factor: 12.310

7.  Positron emission tomography (PET) imaging with (18)F-based radiotracers.

Authors:  Mian M Alauddin
Journal:  Am J Nucl Med Mol Imaging       Date:  2011-12-15

8.  Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues.

Authors:  H J Cassaday; K E Thur
Journal:  Pharmacol Biochem Behav       Date:  2014-12-19       Impact factor: 3.533
  8 in total

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