Literature DB >> 8984149

Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani.

S Ray1, H K Majumder, A K Chakravarty, S Mukhopadhyay, R R Gil, G A Cordell.   

Abstract

A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8984149     DOI： 10.1021/np960018g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

1.  An insight into the active site of a type I DNA topoisomerase from the kinetoplastid protozoan Leishmania donovani.

Authors:  Aditi Das; Chhabinath Mandal; Arindam Dasgupta; Tanushri Sengupta; Hemanta K Majumder
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

2.  Probing the Evolutionary History of Human Bitter Taste Receptor Pseudogenes by Restoring Their Function.

Authors:  Davide Risso; Maik Behrens; Eduardo Sainz; Wolfgang Meyerhof; Dennis Drayna
Journal:  Mol Biol Evol       Date:  2017-07-01       Impact factor: 16.240

3.  Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy.

Authors:  Arnab Roy Chowdhury; Suparna Mandal; Anindya Goswami; Monidipa Ghosh; Labanya Mandal; Debabani Chakraborty; Agneyo Ganguly; Gayatri Tripathi; Sibabrata Mukhopadhyay; Santu Bandyopadhyay; Hemanta K Majumder
Journal:  Mol Med       Date:  2003 Jan-Feb       Impact factor: 6.354

Review 4.  Astonishing diversity of natural surfactants: 7. Biologically active hemi- and monoterpenoid glycosides.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2006-01       Impact factor: 1.880

5.  Topoisomerase I inhibitors and drug resistance.

Authors:  R E Parchment; A Pessina
Journal:  Cytotechnology       Date:  1998-09       Impact factor: 2.058

6.  Sensitive quantitative analysis of the bitter glycoside amarogentin by specific monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay.

Authors:  Seiichi Sakamoto; Shinji Wada; Hiroyuki Tanaka; Satoshi Morimoto
Journal:  RSC Adv       Date:  2018-05-14       Impact factor: 4.036

7.  The bitter barricading of prostaglandin biosynthesis pathway: understanding the molecular mechanism of selective cyclooxygenase-2 inhibition by amarogentin, a secoiridoid glycoside from Swertia chirayita.

Authors:  Shantanu Shukla; Khushboo Bafna; Durai Sundar; Sunil S Thorat
Journal:  PLoS One       Date:  2014-03-06       Impact factor: 3.240

8.  Phytochemical investigation of crude methanol extracts of different species of Swertia from Nepal.

Authors:  Supreet Khanal; Niroj Shakya; Krishna Thapa; Deepak Raj Pant
Journal:  BMC Res Notes       Date:  2015-12-26

Review 9.  A Review of Swertia chirayita (Gentianaceae) as a Traditional Medicinal Plant.

Authors:  Vijay Kumar; Johannes Van Staden
Journal:  Front Pharmacol       Date:  2016-01-12       Impact factor: 5.810

10.  Acyclic Sesquiterpenes from the Fruit Pericarp of Sapindus saponaria Induce Ultrastructural Alterations and Cell Death in Leishmania amazonensis.

Authors:  Amanda Louzano Moreira; Débora Botura Scariot; Bruna Luíza Pelegrini; Greisiele Lorena Pessini; Tânia Ueda-Nakamura; Celso Vataru Nakamura; Izabel Cristina Piloto Ferreira
Journal:  Evid Based Complement Alternat Med       Date:  2017-08-22       Impact factor: 2.629
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.