Literature DB >> 8981470

PACAP immunoreactivity in the rat superior cervical ganglion in comparison to VIP.

L Klimaschewski1, C Hauser, C Heym.   

Abstract

The presence and regulation of pituitary adenylate cyclase activating peptide (PACAP) was investigated in the adult rat superior cervical ganglion. Double-labelling immunofluorescence using specific antibodies against PACAP and vasoactive intestinal peptide (VIP) revealed a dense innervation of postganglionic sympathetic neurones by PACAP-immunoreactive but VIP-negative nerve endings that mainly were of preganglionic origin since they disappeared after transection of the cervical sympathetic trunk. Since PACAP regulates transmitter synthesis and release in sympathetic neurones in vitro, this finding provides a morphological correlate for modulatory effects of PACAP in vivo. Few neurones contained PACAP under normal conditions. However, the number of PACAP-positive neurones increased in response to axotomy of the postganglionic nerves. Many of the newly PACAP-positive neurones also contained VIP, suggesting that both peptides are regulated by similar mechanisms.

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Year:  1996        PMID： 8981470     DOI： 10.1097/00001756-199611040-00078

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  8 in total

1.  Microarray analyses of pituitary adenylate cyclase activating polypeptide (PACAP)-regulated gene targets in sympathetic neurons.

Authors:  Karen M Braas; Kristin C Schutz; Jeffrey P Bond; Margaret A Vizzard; Beatrice M Girard; Victor May
Journal:  Peptides       Date:  2007-04-19       Impact factor: 3.750

2.  PACAP38-Mediated Bladder Afferent Nerve Activity Hyperexcitability and Ca2+ Activity in Urothelial Cells from Mice.

Authors:  Thomas J Heppner; Grant W Hennig; Mark T Nelson; Victor May; Margaret A Vizzard
Journal:  J Mol Neurosci       Date:  2018-07-19       Impact factor: 3.444

3.  Identification of endogenous sympathetic neuron pituitary adenylate cyclase-activating polypeptide (PACAP): depolarization regulates production and secretion through induction of multiple propeptide transcripts.

Authors:  C A Brandenburg; V May; K M Braas
Journal:  J Neurosci       Date:  1997-06-01       Impact factor: 6.167

4.  gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury.

Authors:  Richard E Zigmond
Journal:  Front Mol Neurosci       Date:  2012-01-20       Impact factor: 5.639

5.  Intrabladder PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in Mice Exposed to Repeated Variate Stress (RVS).

Authors:  Beatrice M Girard; Susan E Campbell; Katharine I Beca; Megan Perkins; Harrison Hsiang; Victor May; Margaret A Vizzard
Journal:  J Mol Neurosci       Date:  2020-07-01       Impact factor: 2.866

6.  Origins and neurochemical complexity of preganglionic neurons supplying the superior cervical ganglion in the domestic pig.

Authors:  Judyta K Juranek; Joanna A Wojtkiewicz
Journal:  J Mol Neurosci       Date:  2014-05-23       Impact factor: 3.444

Review 7.  PACAP/Receptor System in Urinary Bladder Dysfunction and Pelvic Pain Following Urinary Bladder Inflammation or Stress.

Authors:  Beatrice M Girard; Katharine Tooke; Margaret A Vizzard
Journal:  Front Syst Neurosci       Date:  2017-12-04

Review 8.  Effect of PACAP in central and peripheral nerve injuries.

Authors:  Andrea Tamas; Dora Reglodi; Orsolya Farkas; Erzsebet Kovesdi; Jozsef Pal; John T Povlishock; Attila Schwarcz; Endre Czeiter; Zalan Szanto; Tamas Doczi; Andras Buki; Peter Bukovics
Journal:  Int J Mol Sci       Date:  2012-07-06       Impact factor: 6.208
  8 in total

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