Literature DB >> 8981411

NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro.

B Malgrange1, P P Lefebvre, D Martin, H Staecker, T R Van de Water, G Moonen.   

Abstract

CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8981411     DOI： 10.1097/00001756-199611040-00019

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  11 in total

1.  Expression of growth factors and their receptors in the postnatal rat cochlea.

Authors:  B Malgrange; B Rogister; P P Lefebvre; C Mazy-Servais; A A Welcher; C Bonnet; R Y Hsu; J M Rigo; T R Van De Water; G Moonen
Journal:  Neurochem Res       Date:  1998-08       Impact factor: 3.996

2.  Regenerated synapses between postnatal hair cells and auditory neurons.

Authors:  Mingjie Tong; Aurore Brugeaud; Albert S B Edge
Journal:  J Assoc Res Otolaryngol       Date:  2013-02-20

3.  Role of brain-derived neurotrophic factor in target invasion in the gustatory system.

Authors:  T Ringstedt; C F Ibáñez; C A Nosrat
Journal:  J Neurosci       Date:  1999-05-01       Impact factor: 6.167

4.  Ras/p38 and PI3K/Akt but not Mek/Erk signaling mediate BDNF-induced neurite formation on neonatal cochlear spiral ganglion explants.

Authors:  Lina M Mullen; Kwang K Pak; Eduardo Chavez; Kenji Kondo; Yves Brand; Allen F Ryan
Journal:  Brain Res       Date:  2011-11-06       Impact factor: 3.252

5.  Effects of brain-derived neurotrophic factor (BDNF) on the cochlear nucleus in cats deafened as neonates.

Authors:  Cherian K Kandathil; Olga Stakhovskaya; Patricia A Leake
Journal:  Hear Res       Date:  2016-10-20       Impact factor: 3.208

6.  Brain-derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats.

Authors:  Patricia A Leake; Gary T Hradek; Alexander M Hetherington; Olga Stakhovskaya
Journal:  J Comp Neurol       Date:  2011-06-01       Impact factor: 3.215

Review 7.  Clinical application of neurotrophic factors: the potential for primary auditory neuron protection.

Authors:  Lisa N Gillespie; Robert K Shepherd
Journal:  Eur J Neurosci       Date:  2005-11       Impact factor: 3.386

Review 8.  Drug delivery for treatment of inner ear disease: current state of knowledge.

Authors:  Andrew A McCall; Erin E Leary Swan; Jeffrey T Borenstein; William F Sewell; Sharon G Kujawa; Michael J McKenna
Journal:  Ear Hear       Date:  2010-04       Impact factor: 3.570

9.  Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons.

Authors:  Jennifer A Chikar; Deborah J Colesa; Donald L Swiderski; Adriana Di Polo; Yehoash Raphael; Bryan E Pfingst
Journal:  Hear Res       Date:  2008-08-19       Impact factor: 3.208

10.  Visualization of spiral ganglion neurites within the scala tympani with a cochlear implant in situ.

Authors:  Jennifer A Chikar; Shelley A Batts; Bryan E Pfingst; Yehoash Raphael
Journal:  J Neurosci Methods       Date:  2009-02-07       Impact factor: 2.390
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.