Literature DB >> 8981312

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

M A Deibel1, W D Ehmann, W R Markesbery.   

Abstract

Copper (Cu), iron (Fe), and zinc (Zn) levels in five different brain regions (amygdala, hippocampus, inferior parietal lobule, superior and middle temporal gyri, and cerebellum) were determined by instrumental neutron activation analysis (INAA) in samples from Alzheimer's disease (AD) patients and age-matched control subjects. A significant decrease in Cu, and significant increases in Zn and Fe were found in AD hippocampus and amygdala, areas showing severe histopathologic alterations in AD. None of these elements were significantly imbalanced in the cerebellum which is minimally affected in AD.

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Year:  1996        PMID： 8981312     DOI： 10.1016/s0022-510x(96)00203-1

Source DB:  PubMed          Journal:  J Neurol Sci        ISSN： 0022-510X            Impact factor:   3.181


  137 in total

1.  Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette's syndrome.

Authors:  Yuval Eliahu Landau; Tamar Steinberg; Brian Richmand; James Frederick Leckman; Alan Apter
Journal:  J Neural Transm (Vienna)       Date:  2011-12-03       Impact factor: 3.575

2.  Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients.

Authors:  Nicole L Bjorklund; V-M Sadagoparamanujam; Giulio Taglialatela
Journal:  J Neurosci Methods       Date:  2011-09-16       Impact factor: 2.390

3.  The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory.

Authors:  Karen M Rodrigue; Ana M Daugherty; E Mark Haacke; Naftali Raz
Journal:  Cereb Cortex       Date:  2012-05-29       Impact factor: 5.357

4.  The effect of formalin fixation on the levels of brain transition metals in archived samples.

Authors:  Matthew Schrag; April Dickson; Arshad Jiffry; David Kirsch; Harry V Vinters; Wolff Kirsch
Journal:  Biometals       Date:  2010-06-26       Impact factor: 2.949

5.  Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls.

Authors:  Steven T Szabo; G Jean Harry; Kathleen M Hayden; David T Szabo; Linda Birnbaum
Journal:  Toxicol Sci       Date:  2015-12-31       Impact factor: 4.849

6.  Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimer's disease.

Authors:  Matthew Schrag; Andrew Crofton; Matthew Zabel; Arshad Jiffry; David Kirsch; April Dickson; Xiao Wen Mao; Harry V Vinters; Dylan W Domaille; Christopher J Chang; Wolff Kirsch
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Review 7.  Oxidative imbalance in Alzheimer's disease.

Authors:  Xiongwei Zhu; Hyoung-Gon Lee; Gemma Casadesus; Jesus Avila; Kelly Drew; George Perry; Mark A Smith
Journal:  Mol Neurobiol       Date:  2005       Impact factor: 5.590

Review 8.  [The role of copper in the pathophysiology of Alzheimer's disease].

Authors:  H Kessler; F-G Pajonk; T Supprian; P Falkai; G Multhaup; T A Bayer
Journal:  Nervenarzt       Date:  2005-05       Impact factor: 1.214

9.  Gender dependent APP processing in a transgenic mouse model of Alzheimer's disease.

Authors:  S Schäfer; O Wirths; G Multhaup; T A Bayer
Journal:  J Neural Transm (Vienna)       Date:  2006-10-31       Impact factor: 3.575

10.  Serum zinc in the progression of Alzheimer's disease.

Authors:  Jiang Dong; J David Robertson; William R Markesbery; Mark A Lovell
Journal:  J Alzheimers Dis       Date:  2008-11       Impact factor: 4.472
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