Literature DB >> 8975702

Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats.

T K Watanabe1, T Katagiri, M Suzuki, F Shimizu, T Fujiwara, N Kanemoto, Y Nakamura, Y Hirai, H Maekawa, E i Takahashi.   

Abstract

From a human fetal-brain cDNA library we isolated two novel genes encoding peptides containing six EGF-like repeats. Both showed significant homologies with nel, a gene strongly expressed in neural tissues of chicken. The cDNAs, designated NELL1 (nel-like, type 1) and NELL2 (nel-like, type 2), contained open reading frames encoding 810 and 816 amino acids, respectively. NELL2 is strongly expressed in brain of adult and fetus but only weakly in fetal kidney. NELL1 and NELL2 were mapped by FISH to chromosomal bands 11p15.1-p15.2 and 12q13.11-q13.12, respectively.

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Year:  1996        PMID： 8975702     DOI： 10.1006/geno.1996.0628

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  44 in total

1.  Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death.

Authors:  Eun Jung Choi; Dong Hee Kim; Jae Geun Kim; Dong Yeol Kim; Jung Dae Kim; Ok Ju Seol; Choon Soo Jeong; Jeong Woo Park; Min Young Choi; Sung Goo Kang; Maria E Costa; Sergio R Ojeda; Byung Ju Lee
Journal:  J Biol Chem       Date:  2010-06-10       Impact factor: 5.157

2.  Type 2 helper T-cell cytokines induce morphologic and molecular characteristics of atopic dermatitis in human skin equivalent.

Authors:  Marijke Kamsteeg; Mieke Bergers; Roelie de Boer; Patrick L J M Zeeuwen; Stanleyson V Hato; Joost Schalkwijk; Geuranne S Tjabringa
Journal:  Am J Pathol       Date:  2011-05       Impact factor: 4.307

Review 3.  The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration.

Authors:  X Zhang; J Zara; R K Siu; K Ting; C Soo
Journal:  J Dent Res       Date:  2010-07-20       Impact factor: 6.116

4.  Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading.

Authors:  Yoko Nakamura; Ai Hasebe; Kaneyoshi Takahashi; Masumi Iijima; Nobuo Yoshimoto; Andrés D Maturana; Kang Ting; Shun'ichi Kuroda; Tomoaki Niimi
Journal:  J Biol Chem       Date:  2014-02-21       Impact factor: 5.157

5.  Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.

Authors:  Naoka Yamamoto; Manabu Kashiwagi; Manami Ishihara; Takaaki Kojima; Andrés D Maturana; Shun'ichi Kuroda; Tomoaki Niimi
Journal:  J Biol Chem       Date:  2019-01-30       Impact factor: 5.157

Review 6.  Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma.

Authors:  Archana Agarwal; Rahul Polineni; Zulfiqar Hussein; Ivette Vigoda; Tushar D Bhagat; Sanchari Bhattacharyya; Anirban Maitra; Amit Verma
Journal:  Int J Clin Exp Pathol       Date:  2012-05-23

7.  Delivery of lyophilized Nell-1 in a rat spinal fusion model.

Authors:  Weiming Li; Min Lee; Julie Whang; Ronald K Siu; Xinli Zhang; Chen Liu; Benjamin M Wu; Jeffrey C Wang; Kang Ting; Chia Soo
Journal:  Tissue Eng Part A       Date:  2010-09       Impact factor: 3.845

8.  Craniosynostosis in transgenic mice overexpressing Nell-1.

Authors:  Xinli Zhang; Shun'ichi Kuroda; Dale Carpenter; Ichiro Nishimura; Chia Soo; Rex Moats; Keisuke Iida; Eric Wisner; Fei-Ya Hu; Steve Miao; Steve Beanes; Catherine Dang; Heleni Vastardis; Michael Longaker; Katsuyuki Tanizawa; Norihiro Kanayama; Naoaki Saito; Kang Ting
Journal:  J Clin Invest       Date:  2002-09       Impact factor: 14.808

9.  Neurexin Superfamily Cell Membrane Receptor Contactin-Associated Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1 (Nell-1)-Responsive Osteogenesis.

Authors:  Chenshuang Li; Zhong Zheng; Pin Ha; Xiaoyan Chen; Wenlu Jiang; Shan Sun; Feng Chen; Greg Asatrian; Emily A Berthiaume; Jong Kil Kim; Eric C Chen; Shen Pang; Xinli Zhang; Kang Ting; Chia Soo
Journal:  J Bone Miner Res       Date:  2018-06-29       Impact factor: 6.741

10.  Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways.

Authors:  Suraiya Rasheed; Jasper S Yan; Adil Hussain; Bruce Lai
Journal:  J Transl Med       Date:  2009-08-27       Impact factor: 5.531
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