Literature DB >> 8975601

Growth inhibition of metronidazole-susceptible and metronidazole-resistant strains of Gardnerella vaginalis by Lactobacilli in vitro.

N W McLean1, J A McGroarty.   

Abstract

Metronidazole resistance was produced in susceptible Gardnerella vaginalis after subculture in the presence of metronidazole. Metronidazole-resistant gardnerellae were less susceptible to growth inhibition by Lactobacillus culture filtrates. A low pH (+/- 4) and lactic acid accounted for 60 to 95% of inhibitory activity, and H2O2 accounted for only 0 to 30%. However, in the presence of myeloperoxidase, H2O2-producing lactobacilli decreased the viability of metronidazole-susceptible gardnerellae 2,000-fold.

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Year:  1996        PMID： 8975601      PMCID： PMC167872          DOI： 10.1128/aem.62.3.1089-1092.1996

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  19 in total

1.  Control of the microbial flora of the vagina by H2O2-generating lactobacilli.

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4.  Electron microscopy of adhesive interactions between Gardnerella vaginalis and vaginal epithelial cells, McCoy cells and human red blood cells.

Authors:  T G Scott; B Curran; C J Smyth
Journal:  J Gen Microbiol       Date:  1989-03

Review 5.  Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action.

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Journal:  J Antimicrob Chemother       Date:  1993-01       Impact factor: 5.790

6.  In vitro interactions between lactobacilli and other microorganisms occurring in the vaginal flora.

Authors:  P A Mårdh; L V Soltész
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8.  Prevention of nitroimidazole resistance in Campylobacter pylori by coadministration of colloidal bismuth subcitrate: clinical and in vitro studies.

Authors:  C S Goodwin; B J Marshall; E D Blincow; D H Wilson; S Blackbourn; M Phillips
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Review 9.  Gardnerella vaginalis: characteristics, clinical considerations, and controversies.

Authors:  B W Catlin
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10.  Hydrogen peroxide production by Lactobacillus species: correlation with susceptibility to the spermicidal compound nonoxynol-9.

Authors:  J A McGroarty; L Tomeczek; D G Pond; G Reid; A W Bruce
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  15 in total

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Review 5.  Managing recurrent bacterial vaginosis.

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9.  Vaginal microbiota and the use of probiotics.

Authors:  Sarah Cribby; Michelle Taylor; Gregor Reid
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10.  Inhibition of vaginal lactobacilli by a bacteriocin-like inhibitor produced by Enterococcus faecium 62-6: potential significance for bacterial vaginosis.

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