Literature DB >> 897345

Biphasic effects of m-chlorophenyl-piperazine on 3,4-dihydroxyphenylacetic acid concentration in rat brain.

R W Fuller, H D Snoddy.   

Abstract

m-Chlorophenyl-piperazine dihydrochloride injected i.p. into rats caused a rapid increase and a subsequent decrease in whole brain concentration of 3,4-dihydroxyphenylacetic acid (DOPAC), a metabolite of dopamine. The increase in DOPAC at 30 min and the decrease at 3 hrs were dose-related and occurred after doses as low as 5 mg/kg of m-chlorophenyl-piperazine dihydrochloride.

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Year:  1977        PMID： 897345

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  3 in total

1.  Trazodone, a central serotonin antagonist and agonist.

Authors:  J Maj; W Palider
Journal:  J Neural Transm       Date:  1979       Impact factor: 3.575

2.  Long-term administration of m-chlorophenylpiperazine (mCPP) to rats induces changes in serotonin receptor binding, dopamine levels and locomotor activity without altering prolactin and corticosterone secretion.

Authors:  J Ulrichsen; J S Partilla; E M Dax
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  Evidence of a preferential role of brain serotonin in the mechanisms leading to naloxone-precipitated compulsive jumping in morphine-dependent rats.

Authors:  L Cervo; C Rochat; S Romandini; R Samanin
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530
  3 in total

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